Gulf War illness with or without post-traumatic stress disorder:differential symptoms and immune responses  

作　　者：Faith Nguyen Ashok K.Shetty 

机构地区：[1]Department of Cell Biology and Genetics,School of Medicine,Institute for Regenerative Medicine,Texas A&M University Health Science Center,1114 TAMU,206 Olsen Boulevard,College Station,TX 77843,USA

出　　处：《Military Medical Research》2025年第2期311-312,共2页军事医学研究(英文版)

基　　金：Department of Defense(W81XWH-17-1-0447 and W81XWH1910548 to AKS);Texas A&M University School of Medicine。

摘　　要：Over one-third of 700,000 military personnel who served in the first Gulf War(GW)suffer from an assortment of symptoms,including cognitive and memory problems,musculoskeletal pain,gastrointestinal discomfort,fatigue,and respiratory issues[1,2].The precise etiology of Gulf War illness(GWI)is unclear.However,epidemiological and preclinical studies imply that exposures to the prophylactic drug pyridostigmine bromide,insecticides,pesticides,smoke from oil well fires,and interaction between these exposures and war-related stress underlie this illness[2].As per the Kansas case definition,GWI is a chronic multi-symptom illness displaying one moderately severe and/or multiple symptoms of any severity in at least 3 of 6 symptom domains(fatigue,pain,neurological/cognitive/mood,skin,gastrointestinal,respiratory)[1,2].While the exact pathophysiological changes underlying GWI have not been identified,alterations in immune regulation and dysregulation of the redox balance have been observed in GWI,resulting in chronic systemic inflammation and neuroinflammation[2].

关 键 词：Gulf War illness Immune response INTERLEUKIN-15 Natural killer cells Post-traumatic stress disorder T lymphocytes 

分 类 号：R749.5[医药卫生—神经病学与精神病学]