中晚期肺癌患者不同治疗方案对生命质量的影响  

Effects of quality of life in patients with intermediate and advanced lung cancer undergoing different treatment regimens

作　　者：王越 黄晓彤 赵菲 丁莉莉 吴炳义 WANG Yue;HUANG Xiaotong;ZHAO Fei;Ding Lili;WU Bingyi(School of Management,Shandong Second Medical University,Weifang,Shandong 261053,China;School of Nursing,Shandong Second Medical University,Weifang,Shandong 261053,China)

机构地区：[1]山东第二医科大学管理学院,山东潍坊261053 [2]山东第二医科大学护理学院,山东潍坊261053

出　　处：《预防医学》2025年第3期272-275,共4页China Preventive Medicine Journal

基　　金：国家社会科学基金课题重点项目(23ARK001);山东省自然科学基金项目(ZR2022MG007)。

摘　　要：目的探讨化疗/放疗、靶向治疗和联合治疗3种治疗方案对中晚期肺癌患者生命质量的影响。方法于2023年9月,采用定额抽样方法抽取山东省潍坊市某三甲医院进行化疗/放疗、靶向治疗和联合治疗的中晚期肺癌患者为研究对象,采用一般调查表收集基本信息,采用中文版癌症患者生命质量测定量表评价生命质量;治疗7 d进行调查,3个月和6个月随访调查,采用重复测量资料的方差分析比较不同治疗方案、不同治疗时间患者的生命质量得分。结果化疗/放疗患者26例、靶向治疗患者32例、联合治疗患者95例;3种治疗方案患者的年龄、性别、居住地、文化程度、自评经济状况、医疗保险、病理类型和疾病分期比较,差异无统计学意义(均P>0.05)。重复测量资料的方差分析结果显示,3种治疗方案患者生命质量得分的时间与组间存在交互效应(P<0.05),联合治疗患者的生命质量得分随治疗时间延长而下降(均P<0.05),治疗3个月和6个月的靶向治疗患者生命质量得分低于治疗7 d(均P<0.05),不同治疗时间的化疗/放疗患者生命质量得分差异无统计学意义(均P>0.05);治疗3个月和6个月后,联合治疗患者的生命质量得分低于化疗/放疗和靶向治疗患者(均P<0.05)。结论化疗/放疗和靶向治疗的中晚期肺癌患者生命质量下降幅度小于联合治疗。Objective To examine the impacts of chemotherapy/radiotherapy,targeted therapy,and combined treatment on the quality of life in patients with intermediate and advanced lung cancer.Methods The patients with intermediate and advanced lung cancer undergoing chemotherapy/radiotherapy,targeted therapy,and combined treatment for the first time were recruited from a tertiary hospital in Weifang City,Shandong Province,using a quota sampling method in September 2023.Basic information was collected using a general information questionnaire,and the quality of life was assessed using the Chinese version of Functional Assessment of Cancer Therapy-General.The investigation started on the 7th day of treatment,and the follow-ups were conducted at 3 and 6 months.The quality of life in patients with different treatment regimens and at different treatment time were compared using repeated measure analysis of variance.Results There were 26 chemotherapy/radiotherapy patients,32 targeted therapy patients,and 95 combination therapy patients.There were no significant differences in age,gender,place of residence,education level,self-rated economic status,medical insurance,pathological type and disease stage among the three treatment regimens(all P>0.05).The repeated measure analysis of variance showed an interaction effect between time and group among patients receiving the three treatment regimens(P<0.05).The quality of life scores of patients receiving combination therapy decreased with extended treatment time(all P<0.05).The quality of life scores of patients receiving targeted therapy at 3 and 6 months were lower than those treated for 7 days(both P<0.05).No significant differences were observed in quality of life scores among chemotherapy/radiotherapy patients with different treatment durations(all P>0.05).At 3 and 6 months,patients receiving combination therapy had lower quality of life scores compared to those receiving chemotherapy/radiotherapy or targeted therapy(all P<0.05).Conclusion The decline in quality of life for patients

关 键 词：生命质量 肺癌 治疗方案 

分 类 号：R734.2[医药卫生—肿瘤]