番禺区女性乳腺癌患者生存分析  

Survival analysis of female breast cancer patients in Panyu District

作　　者：由娜 梁小娴 赖春燕 阮慧红 YOU Na;LIANG Xiaoxian;LAI Chunyan;RUAN Huihong(Panyu District Center for Chronic Disease Control,Guangzhou,Guangdong 511400,China;Panyu District Center for Disease Control and Prevention,Guangzhou,Guangdong 511400,China;Panyu District Hualong Town Community Health Service Center,Guangzhou,Guangdong 511400,China)

机构地区：[1]广州市番禺区慢性病防治站,广东广州511400 [2]广州市番禺区疾病预防控制中心,广东广州511400 [3]广州市番禺区化龙镇社区卫生服务中心,广东广州511400

出　　处：《预防医学》2025年第3期321-324,共4页China Preventive Medicine Journal

基　　金：番禺区科技计划项目(2022-Z04-061)。

摘　　要：目的了解广州市番禺区女性乳腺癌患者生存率,为改善乳腺癌患者预后提供依据。方法通过广州市癌症登记报告管理系统收集2017年确诊的番禺区户籍女性乳腺癌患者的年龄、临床分期和手术治疗等基本资料,随访生存情况,随访终点日期为2022年12月31日。采用寿命表法计算生存率,采用多因素Cox比例风险回归模型分析女性乳腺癌患者生存时间的影响因素。结果2017年番禺区报告女性乳腺癌227例,年龄M(QR)为51(17)岁。临床分期为Ⅰ期43例,占18.94%;Ⅱ期55例,占24.23%;Ⅲ期63例,占27.75%;Ⅳ期27例,占11.89%;不明39例,占17.18%。手术治疗204例,占89.87%。化疗73例,占32.16%。截至2022年12月31日,死亡40例,失访14例。1年、3年和5年生存率分别为96.44%、87.45%和82.87%。多因素Cox比例风险回归分析结果显示,年龄大(HR=1.023,95%CI:1.002~1.046)、临床分期为Ⅲ期(HR=10.050,95%CI:1.324~76.270)或Ⅳ期(HR=42.663,95%CI:5.588~325.742)的女性乳腺癌患者死亡风险较高,手术治疗(HR=0.278,95%CI:0.130~0.598)的女性乳腺癌患者死亡风险较低。结论番禺区女性乳腺癌患者5年生存率为82.87%,年龄、临床分期和手术治疗是女性乳腺癌患者生存时间的主要影响因素。Objective To investigate the survival rate of female breast cancer patients in Panyu District,Guangzhou City,so as to provide the basis for improving the prognosis of breast cancer patients.Methods Basic information including age,clinical stage and surgical treatment of female breast cancer patients registered in Panyu District and diagnosed in 2017 were collected through the Guangzhou Municipal Cancer Registration and Reporting Management System,and were followed up until December 31,2022.The survival rate was calculated using the life table.Factors affecting survival time among female breast cancer patients were analyzed using a multivariable Cox proportional hazard regression model.Results A total of 227 female breast cancer patients were reported in Panyu District in 2017,and had a median age of 51(interquartile range,17)years.There were 43 cases(18.94%)in stage Ⅰ,55 cases(24.23%)in stage Ⅱ,63 cases(27.75%)in stage Ⅲ,27 cases(11.89%)in stage Ⅳ,and 39 cases(17.18%)with unknown staging.Surgical treatment was performed in 204 cases(89.87%),and chemotherapy was administered in 73 cases(32.16%).By December 31,2022,there were 40 deaths and 14 patients lost to follow-up.The one-year,three-year and five-year survival rates were 96.44%,87.45%and 82.87%,respectively.Multivariable Cox proportional hazard regression analysis showed that older age(HR=1.023,95%CI:1.002-1.046),clinical stage Ⅲ(HR=10.050,95%CI:1.324-76.270)or Ⅳ(HR=42.663,95%CI:5.588-325.742)were associated with a higher risk of mortality in female breast cancer patients,while surgical treatment(HR=0.278,95%CI:0.130-0.598)was associated with a lower risk of mortality.Conclusions The five-year survival rate of female breast cancer patients in Panyu District was 82.87%.Age,clinical stage and surgical treatment were the main influencing factors for the survival time of female breast cancer patients.

关 键 词：乳腺癌 生存率 生存分析 影响因素 

分 类 号：R737.9[医药卫生—肿瘤]