山茱萸化学成分和药理作用的研究进展  

Research progress on chemical composition and pharmacology of Cornus officinalis

作　　者：汪嘉俊 王泽萍 王雪莲 贾旨乐 明家和 曹岗[1] 韩欣 WANG Jiajun;WANG Zeping;WANG Xuelian;JIA Zhile;MING Jiahe;CAO Gang;HAN Xin(College of Pharmacy,Zhejiang Chinese Medical University,Hangzhou 311400,China)

机构地区：[1]浙江中医药大学药学院,浙江杭州311400

出　　处：《中草药》2025年第3期1088-1103,共16页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金青年科学基金项目(82104394);浙江省基础公益研究项目(LY23H280008)。

摘　　要：山茱萸Cornus officinalis作为中国传统重要中药品种之一,资源丰富,其成分、药理作用多样,具有极大药用价值。目前从山茱萸中分离鉴定出多种化学物质,包括环烯醚萜类及其苷、三萜类、有机酸类、黄酮类、多糖等;药理作用主要有抗肿瘤、降血糖、保护神经元、抗氧化和抗炎等。通过检索近20年国内外相关文献,对山茱萸的主要化学成分、药理作用进行综述,为探究山茱萸的现代临床作用的机制方面提供新的思路和方向。Cornus officinalis,as one of the important traditional Chinese medicinal varieties in China,is rich in resources,with a variety of constituents,pharmacological effects and great medicinal value.At present,a variety of chemical substances have been isolated and identified from C.officinalis,including iridoid terpenoids and their glycosides,triterpenoids,organic acids,flavonoids,polysaccharides,etc.;and the pharmacological effects mainly include antitumor,hypoglycemia,neuron protection,antioxidant and anti-inflammatory.In this manuscript,the main chemical constituents and pharmacological effects of C.officinalis are reviewed by searching the relevant literature at home and abroad in the past 20 years,with a view to providing new ideas and directions for the study of C.officinalis’mechanism in modern clinical practice.

关 键 词：山茱萸 环烯醚萜类 鞣质类 黄酮类 降血糖 抗肿瘤 神经保护 抗炎 抗氧化 

分 类 号：R28[医药卫生—中药学]