基于临床病理特征分析肺癌术后病原菌感染影响因素及与炎症因子关系  

Based on clinicopathological features,the relationship between pathogenic bacterial infection and inflammatory factors after chemotherapy for lung cancer was analyzed

作　　者：刘芬 郭喜喜[2] 郭利敏[3] LIU Fen;GUO Xixi;GUO Limin(Xinriang Central Hospital,the Fourth Department of Clinical Pathology,Xinziang Medical College,Xinxiang 453000,Henan,China;Xinriang Central Hospital,the Fourth Clinical Medicine Department of Thoracic Oncology,Xinziang Medical College,Xinxiang 453000,Henan,China;Xinciang Central Hospital,the Fourth Clinical Laboratoryof Xinciang Medical College,Xinxiang 453000,Henan,China)

机构地区：[1]新乡市中心医院,新乡医学院第四临床医学病理科,河南新乡453000 [2]新乡市中心医院,新乡医学院第四临床医学胸瘤科,河南新乡453000 [3]新乡市中心医院,新乡医学院第四临床医学检验科,河南新乡453000

出　　处：《中国病原生物学杂志》2025年第4期503-507,共5页Journal of Pathogen Biology

摘　　要：目的探究基于临床病理特征分析肺癌术后病原菌感染影响因素及其与炎症因子的关系。方法达选取2022年5月至2024年10月于本院进行肺癌手术治疗的肺癌患者68例并根据患者术后感染情况分为感染组(n=23)和未感染组(n=45)。采用酶联免疫吸附(ELISA)法测定肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平。单因素分析感染组和未感染组患者临床病理特征差异;Logistic回归分析肺癌术后病原菌感染影响因素;对比感染组和未感染组患者炎症因子水平(TNF-α、IL-6、IL-8)差异;ROC分析TNF-α、IL-6、IL-8联合检测对肺癌术后病原菌感染诊断价值。结果感染组合并慢性肺部疾病、开胸手术方式、术后PaCO,<90、血清白蛋白<35占比均明显高于未感染组(均P<0.05);Logistic回归分析结果显示合并慢性肺部疾病、手术方式未开胸、术后PaCO_(2)<90%、血清白蛋白<35g/L、EGFR基因突变和病理特征为鳞癌是肺癌术后病原菌感染发生的危险因素(P<0.05);感染组TNF-α、IL-6、IL-8水平均明显高于未感染组(均P<0.05);ROC结果显示,TNF-α、IL-6、IL-8联合检测对肺癌术后病原菌感染具有较高诊断价值(AUC:0.964),但联合检测诊断敏感度(95.56%)和特异度(95.65%)显著高于单独检测(P<0.05)。结论合并慢性肺部疾病、开胸手术、术后PaCO_(2)偏低、血清白蛋白低、EGFR基因突变和病理特征为鳞癌的肺癌患者术后病原菌感染风险高。感染组炎症因子TNF-α、IL-6、IL-8水平显著高于未感染组,且炎症因子联合检测对感染诊断价值高,敏感度与特异度良好。提示临床可据此识别高危患者并辅助诊断,改善患者预后。Objective To explore the relationship between pathogenic bacterial infection and inflammatory factors after lung cancer surgery based on clinicopathological characteristics.MethodsSSixty-eight patients with lung cancer who received surgical treatment for lung cancer in our hospital from May 2022 to October 2024 were selected and divided into infected group(n=23)and uninfected group(n=45)according to postoperative infection.Tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-8(IL-8)levels were determined by enzyme-linked immunosorbent assay(ELISA).The difference of clinicopathological features between infected group and uninfected group was analyzed by single factor analysis.The influencing factors of postoperative pathogenic bacterial infection were analyzed by Logistic regression.The levels of inflammatory cytokines(TNF-α,IL-6,IL-8)were compared between infected and uninfected groups.The diagnostic value of TNF-α,IL-6 and IL-8 combined detection for postoperative lung cancer infection was analyzed by ROC.Results Infection combination,chronic lung disease,thoracotomy,PaCO_(2)<90 and serum albumin<35 were significantly higher than those in non-infection group(all P<0.05).Logistic regression analysis showed that chronic lung disease,no thoracotomy,postoperative PaCO_(2)<90%,serum albumin<35 g/L,EGFR gene mutation and pathological characteristics of squamous cell carcinoma were risk factors for postoperative bacterial infection of lung cancer(P<0.05).The levels of TNF-α,IL-6 and IL-8 in infected group were significantly higher than those in non-infected group(all P<0.05).ROC results showed that the combined detection of TNF-α,IL-6 and IL-8 had high diagnostic value for postoperative lung cancer infection(AUC:0.964),but the diagnostic sensitivity(95.56%)and specificity(95.65%)of the combined detection were significantly higher than that of the single detection(P<0.05).Conclusion Lung cancer patients with chronic lung disease,thoracotomy,low PaCO_(2),low serum albumin,EGFR gene mutation and squamo

关 键 词：肺癌 术后病原菌感染 炎症因子 临床病理特征 危险因素 诊断价值 

分 类 号：R73[医药卫生—肿瘤]