MicroRNAs在肺癌治疗中的作用  

Roles of microRNAs in lung cancer therapy

作　　者：臧国杰 刘巾玮 ZANG Guojie;LIU Jinwei(School of Pharmacy,Inner Mongolia Medical University,Hohhot 010107,China;Department of Pharmacy,Chifeng Hospital,Chifeng 024000,China)

机构地区：[1]内蒙古医科大学药学院,呼和浩特010107 [2]赤峰市医院药剂科,赤峰024000

出　　处：《生命的化学》2025年第2期291-300,共10页Chemistry of Life

基　　金：中华医学会临床药学专项基金项目(2022037);公立医院科研联合基金科技项目(2023GLLHO300)。

摘　　要：肺癌是全球最常见的癌症类型之一,也是致死率最高的癌症之一,尽管其治疗取得了重要进展,但情况仍不容乐观,早期诊断困难、肺癌复发率高、耐药性高已成为影响肺癌预后的关键因素。近年来,研究发现,微小RNA(microRNAs,miRNAs)通过控制癌基因表达的表观遗传以及调节肿瘤抑制基因成为癌症的关键调节因子。影响肺癌的几个主要miRNAs(如miR-21、miR-155、miR-34等)通常被发现在肺癌组织中高表达,其与肿瘤的增殖、转移和耐药性有关。因此,研究miRNAs与肺癌的相关性具有重要的意义。本文综合了近年来针对与肺癌相关miRNAs的研究与报道,探讨了其作为生物标志物在肺癌的诊断、治疗及预后评估中的潜在临床意义。Lung cancer is one of the most common types of cancer and one of the most lethal cancers in the world.Despite significant advances in the treatment of lung cancer,the outlook remains concerning.Challenges such as the difficulty of early diagnosis,the high recurrence rate of the disease,and the development of drug resistance continue to be critical factors influencing patient prognosis.In recent years,microRNAs have been found to be key regulators of cancer by controlling the epigenetic expression of oncogenes as well as regulating tumor suppressor genes.Several miRNAs affecting lung cancer,such as miR-21,miR-155,and miR-34,are usually found to be highly expressed in lung cancer tissues,and they are associated with tumor proliferation,metastasis,and drug resistance.Therefore,it is of great significance to study the correlation between miRNAs and lung cancer.In this paper,we synthesize the studies and reports on miRNAs related to lung cancer in recent years,and explore the potential clinical significance of the existence of miRNAs as biomarkers for diagnosis,treatment and prognosis in lung cancer.

关 键 词：MIRNAS 肺癌 预后 生物标志物 

分 类 号：R73[医药卫生—肿瘤]