iTBS模式重复经颅磁刺激联合丙戊酸镁、舍曲林治疗青少年抑郁症的效果  

The effect of iTBS mode repetitive transcranial magnetic stimulation combined with magnesium valproate and sertraline in the treatment of adolescent depression

作　　者：李赛民 沈道银 LI Saimin;SHEN Daoyin(Department Two of Psychology,Guangzhou Baiyun Psychological Hospital,Guangzhou 510000,China;Zone Two of Psychiatry Department,Guangzhou Baiyun Psychological Hospital,Guangzhou 510000,China)

机构地区：[1]广州白云心理医院,心理二科,广东广州510000 [2]广州白云心理医院,精神科二区,广东广州510000

出　　处：《心理月刊》2024年第23期148-150,共3页

摘　　要：目的 探讨iTBS模式重复经颅磁刺激联合丙戊酸镁、舍曲林治疗青少年抑郁症的效果。方法 选取2023年1月~2024年5月期间广州白云心理医院收治的80例青少年抑郁症患者,以随机数字表法分组,对照组40例采取丙戊酸镁、舍曲林治疗,观察组在对照组基础上联合iTBS模式重复经颅磁刺激,比较两组治疗效果。正态计量资料以t检验,计数资料以x^(2)检验。结果 两组治疗前的汉密尔顿抑郁量表(HAMD)、临床总体印象量表-疾病严重程度分量表(CGI-SI)、情绪智力量表(EIS)评分无显著差异(P>0.05),经干预后,上述指标水平与对照组比较有显著差异(P<0.05);两组治疗前的个体和社会功能量表(PSP)、蒙特利尔认知评估量表(MoCA)、匹茨堡睡眠质量指数(PSQI)评分无显著差异(P>0.05),经干预后,上述指标水平与对照组比较有显著差异(P<0.05);两组治疗前的自杀态度问卷(QSA)各维度评分无显著差异(P>0.05),经干预后,上述指标水平与对照组比较有显著差异(P<0.05);观察组治疗总有效率为97.50%,较对照组的80.00%高(P<0.05)。结论 i TBS模式重复经颅磁刺激联合丙戊酸镁、舍曲林治疗青少年抑郁症的效果显著,可有效减轻抑郁症状,提高认知功能与社会功能、睡眠质量,也能调节其自杀态度。Objective To investigate the efficacy of iTBS mode repetitive transcranial magnetic stimulation combined with magnesium valproate and sertraline in the treatment of adolescent depression.Methods 80 adolescent patients with depression admitted to Guangzhou Baiyun Mental Hospital from January 2023 and May 2024 were randomly divided into two groups using a random number table method.The control group consisted of 40 patients treated with magnesium valproate and sertraline,while the observation group received repeated transcranial magnetic stimulation in iTBS mode on top of the control group.The treatment effects of the two groups were compared.T test was used for normal measurement data,and x^(2) test was used for count data.Results There were no significant difference in the Hamilton depression rating scale(HAMD),clinical general impression scale disease severity scale(CGI-SI),and emotional intelligence scale(EIS)scores between the two groups before treatment(P>0.05).After intervention,the levels of these indicators were significantly different from those in the control group(P<0.05).There were no significant difference in the scores of the personal and social performance scale(PSP),Montreal cognitive assessment scale(MoCA),and Pittsburgh sleep quality index scale(PSQI)between the two groups before treatment(P>0.05).After intervention,the levels of these indicators were significantly different from those in the control group(P<0.05).There was no significant difference in the scores of various dimensions of the suicide attitude questionnaire(QSA)between the two groups before treatment(P>0.05).After intervention,there was a significant difference in the levels of the above indicators compared with the control group(P<0.05).The total effective rate of the observation group was 97.50%,which was higher than the control group's 80.00%(P<0.05).Conclusion The iTBS mode repeated transcranial magnetic stimulation combined with magnesium valproate and sertraline is effective in treating adolescent depression.It can effectivel

关 键 词：重复经颅磁刺激 间歇性θ脉冲刺激 丙戊酸镁 舍曲林 青少年抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]