血浆置换治疗在急性坏死性脑病中的应用  

The application of plasma exchange in the treatment of acute necrotizing encephalopathy

作　　者：武宇辉 Wu Yuhui(Department of Pediatric Intensive Core Unit,Affiliated Shenzhen Children's Hospital of Shantou University Medical College,Shenzhen 510026,China)

机构地区：[1]汕头大学医学院附属深圳儿童医院儿童重症医学科,510026

出　　处：《中国小儿急救医学》2025年第2期98-102,共5页Chinese Pediatric Emergency Medicine

基　　金：深圳市“医疗卫生三名工程”项目资助(SZSM202211034)。

摘　　要：急性坏死性脑病常见于病毒感染后伴随的中枢神经系统障碍。感染后宿主过度的全身性免疫应答异常引起的细胞因子风暴可能是急性坏死性脑病的重要发病机制。目前仍缺乏标准化的治疗方案共识。主要的治疗方法包括免疫治疗、抗细胞因子治疗及对症支持治疗等。血浆置换是常用的免疫治疗方法之一,目前缺乏高质量循证医学证据证实其有效性,但仍是有前景的治疗手段,有待进一步的探索。Acute necrotic encephalopathy(ANE)is commonly associated with central nervous system disorders following viral infection.The cytokine storm caused by the abnormal systemic immune response of the host after infection may be an important pathogenesis of ANE.There is still a lack of consensus on standardized treatment options.The main therapeutic methods include immunotherapy,anticytokine therapy and symptomatic supportive therapy.Plasma exchange is one of the commonly used immunotherapy methods.At present,there is a lack of high evidence-based medical study evidence to confirm the effectiveness,but it is still a promising treatment and needs further exploration.

关 键 词：血浆置换 急性坏死性脑病 儿童 

分 类 号：R742[医药卫生—神经病学与精神病学]