川西合耳菊地上部分的化学成分研究  

Study on the chemical constituents in the aerial part of Synotis solidaginea

作　　者：蔡璐瑶 宋尚红 王光燕 黄世伟 张宇佳 何小凤 吕光华[1,2,3] CAI Luyao;SONG Shanghong;WANG Guangyan;HUANG Shiwei;ZHANG Yujia;HE Xiaofeng;LV Cuanghua(State Key Laboratory of Southwestern Chinese Medicine Resources,School of Pharmacy,Chengdu University of TCM,Chengdu,Sichuan,611137 P.R.China;Research Institute of Chinese Medicine as Drug&Food,Chengdu University of TCM,Chengdu,Sichuan,611137 P.R.China;School of Ethnic Medicine,Chengdu University of TCM,Chengdu,Sichuan,611137 P.R.China)

机构地区：[1]成都中医药大学药学院西南特色中药资源国家重点实验室,四川成都611137 [2]成都中医药大学药食两用中药研究所,四川成都611137 [3]成都中医药大学民族医药学院,四川成都611137

出　　处：《华西药学杂志》2025年第1期1-5,共5页West China Journal of Pharmaceutical Sciences

基　　金：四川省药品监督管理局中药(民族药)标准提升项目(510201201904914);四川省高校科研创新团队建设计划项目(18TD0017)。

摘　　要：目的研究川西合耳菊地上部分的化学成分。方法依次用石油醚、乙酸乙酯和正丁醇萃取川西合耳菊地上部分的70%乙醇提取物,取正丁醇部分,用硅胶、葡聚糖凝胶柱层析法分离纯化,核磁共振波谱法鉴定化合物的结构。结果分离得到了8个单体化合物,分别鉴定为(4S,5R,7Z)-12-O-β-D-glucopyranosyl-eremophil-7(11),9-dien-8-one(Ⅰ)、(4S,5R,7E)-12-O-β-D-glucopyranosyl-eremophil-7(11),9-dien-8-one(Ⅱ)、(4S,5R,7S,11Z)-12-O-β-D-glucopyranosyl-eremophil-9,11(12)-dien-8-one(Ⅲ)、(4S,5R,7S,11E)-12-O-β-D-glucopyranosyl-eremophil-9,11(12)-dien-8-one(Ⅳ)、槲皮素(Ⅴ)、金丝桃苷(Ⅵ)、芦丁(Ⅶ)、烟花苷(Ⅷ)。结论化合物Ⅰ~Ⅳ为首次从川西合耳菊中分离得到。OBJECTIVE To study the chemical constituents in the aerial part of Synotis solidaginea.METHODS The 70%ethanol extract of S.solidaginea was successively extracted with petroleum ether,ethyl acetate and n-butanol.The n-butanol extract was further separated and purified by column chromatography of silica gel and Sephadex.The structure of single compound was identified by NMR.RESULTS Eight compounds were isolated and identified as(4S,5R,7Z)-12-O-β-D-glucopyranosyl-eremophil-7(11),9-dien-8-one(Ⅰ),(4S,5R,7E)-12-O-β-D-glucopyranosyl-eremophil-7(11),9-dien-8-one(Ⅱ),(4S,5R,7S,11Z)-12-O-β-D-glucopyranosyl-eremophil-9,11(12)-dien-8-one(Ⅲ),(4S,5R,7S,11E)-12-O-β-D-glucopyranosyl-eremophil-9,11(12)-dien-8-one(Ⅳ),quercetin(Ⅴ),hyperoside(Ⅵ),rutin(Ⅶ),and kaempferol-3-rutinoside(Ⅷ).CONCLUSION CompoundsⅠ-Ⅳwere isolated from S.solidaginea for the first time.

关 键 词：川西合耳菊 地上部分 化学成分 柱色谱法 结构鉴定 核磁共振波谱法 倍半萜 黄酮 

分 类 号：R914[医药卫生—药物化学]