鲁拉西酮对精神分裂症患者Hcy、BDNF及GDNF水平的影响  

Effects of Lurasidone on Levels of Hcy,BDNF and GDNF in Patients with Schizophrenia

作　　者：王炎 梁锋 胡蓉 王冠中 WANG Yan;LIANG Feng;HU Rong;WANG Guanzhong(Jiangxi Provincial Psychiatric Hospital,Nanchang 330029,Jiangxi,China)

机构地区：[1]江西省精神病院,江西南昌330029

出　　处：《现代诊断与治疗》2024年第23期3477-3480,3489,共5页Modern Diagnosis and Treatment

摘　　要：目的 探究鲁拉西酮对精神分裂症患者Hcy、BDNF及GDNF水平的影响。方法 选取我院2020年1月至2023年12月收治的80例精神分裂症患者为研究对象,采用随机数字表法分为对照组和观察组各40例。对照组给予利培酮治疗,观察组给予鲁拉西酮治疗,评估并比较两组的临床疗效,认知功能相关血液指标、不良反应发生情况、症状改善情况、焦虑抑郁情况、阴性症状各项分值。结果 观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组Hcy、BDNF和GDNF水平比较差异无统计学意义(P>0.05);治疗后,观察组Hcy低于对照组,BDNF和GDNF高于对照组,差异有统计学意义(P<0.05)。观察组的不良反应发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组一般精神病理、阳性症状和阴性症状评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组SAS和SDS评分低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的冷漠、思维贫乏、缺乏意志、缺乏社会交往和注意力障碍得分低于对照组,差异有统计学意义(P<0.05)。结论 将鲁拉西酮用于精神分裂症患者治疗效果较好,可改善患者临床症状、认知功能、精神状态,减少不良反应发生情况。Objectives To investigate the effects of lurasidone on the levels of Homocysteine(Hcy),brain-derived neurotrophic factor(BDNF)and glial derived neurotrophic factor(GDNF)in patients with schizophrenia.Methods A total of 80 patients with schizophrenia admitted to our hospital from January 2020 to December 2023 were selected and randomly divide into control group and observation group,with 40 cases in each group.The control group was treated with risperidone,while the observation group was treated with lurasidone.The clinical efficacy,cognitive function-related blood indicators,adverse reactions,symptom improvement,anxiety and depression,and negative symptom scores of the two groups were evaluated and compared.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Before treatment,there was no statistically significant difference in the levels of Hcy,BDNF,and GDNF between the two groups(P>0.05).After treatment,Hcy of the observation group was significantly lower than that of the control group,andBDNF and GDNF were significantly higher than those of the control group(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).After treatment,the scores of general psychopathology,positive symptoms,and negative symptoms inthe observation group were significantly lower than those in the control group(P<0.05).After treatment,the SAS(Self Rating Anxiety Scale)and SDS(Self Rating Depression Scale)scores in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the scores of apathy,poor thinking,lack of willpower,lack of social interaction,and attention deficit in the observation group were significantly lower than those in the control group.Conclusions Lurasidone can improve clinical symptoms,cognitive function and mental state of patients with schizophrenia and reduce the occurrence of adverse reactions.

关 键 词：鲁拉西酮 精神分裂症 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]