三孔腹腔镜胆囊切除术治疗急性胆囊炎的效果及对IL-6、Cor、ACTH水平的影响  

Effect of three-hole laparoscopic cholecystectomy on acute cholecystitis and its influences on IL-6, Cor and ACTH levels

作　　者：许小兵 XU Xiaobing(General Surgery Department,Susong Hospital of Traditional Chinese Medicine,Susong 246501,China)

机构地区：[1]宿松县中医院普外科,安徽宿松246501

出　　处：《临床医学研究与实践》2025年第8期78-81,共4页Clinical Research and Practice

摘　　要：目的分析三孔腹腔镜胆囊切除术治疗急性胆囊炎的效果及对白细胞介素-6(IL-6)、皮质醇(Cor)、促肾上腺皮质激素(ACTH)水平的影响。方法选取2022年3月至2023年10月我院收治的76例急性胆囊炎患者为研究对象,采用SPSS软件将其随机分为对照组和观察组,每组38例。对照组接受传统开腹胆囊切除术治疗,观察组接受三孔腹腔镜胆囊切除术治疗。比较两组的手术指标、临床疗效、炎症指标、应激指标及不良事件发生情况。结果观察组的手术时间、肛门排气时间及住院时间短于对照组,术中出血量少于对照组,差异具有统计学意义(P<0.05)。观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。术后,两组的C反应蛋白(CRP)、IL-6水平均升高,但观察组低于对照组,差异具有统计学意义(P<0.05)。术后,两组的Cor、ACTH水平均升高,但观察组低于对照组,差异具有统计学意义(P<0.05)。观察组的不良事件总发生率低于对照组,差异具有统计学意义(P<0.05)。结论三孔腹腔镜胆囊切除术治疗急性胆囊炎的效果显著,可缩短手术时间,减少术中出血量,减轻术后炎症反应和应激反应,显著降低不良事件发生风险,具有临床推广及应用价值。Objective To analyze the effect of three-hole laparoscopic cholecystectomy on acute cholecystitis and its influences on interleukin-6(IL-6),cortisol(Cor)and adrenocorticotrophic hormone(ACTH)levels.Methods A total of 76 patients with acute cholecystitis admitted in our hospital from March 2022 to October 2023 were selected as the research objects.The patients were randomly divided into control group and observation group by SPSS software,with 38 cases in each group.The control group was treated with traditional open cholecystectomy,and the observation group was treated with three-hole laparoscopic cholecystectomy.The surgical indexes,clinical efficacy,inflammatory indexes,stress indexes and adverse events were compared between the two groups.Results The operation time,anal exhaust time and hospitalization time of the observation group were shorter than those of the control group,the intraoperative blood loss was less than that of the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After operation,the levels of C-reactive protein(CRP)and IL-6 in the two groups increased,but those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).After operation,the levels of Cor and ACTH in the two groups increased,but those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).The total incidence of adverse events in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Three-hole laparoscopic cholecystectomy in the treatment of acute cholecystitis has significant effect,it can shorten the operation time,reduce the intraoperative blood loss,relieve postoperative inflammatory response and stress response,and significantly reduce the risk of adverse e

关 键 词：三孔腹腔镜胆囊切除术 急性胆囊炎 炎症反应 应激反应 

分 类 号：R575.61[医药卫生—消化系统]