Esophageal cancer burden attributable to alcohol use and low consumption of vegetables from 1990 to 2021 across countries with different sociodemographic characteristics  

作　　者：Yi-Kai Ma Yue-Ting Zhou Cai-Xia Liu 

机构地区：[1]Department of Preventive Medicine,Shantou University Medical College,Shantou 515041,Guangdong,China

出　　处：《Journal of Nutritional Oncology》2025年第1期21-28,共8页肿瘤营养学杂志(英文)

基　　金：The Science and Technology Planning Project of Shantou in 2021(No.210616086490125);the Guangdong Department of Education’s SpecialGrant for Key Area Programs(No.2021ZDZX2023);the National Natural Science Foundation of China(No.82072607,No.81871975)all provided funding for this work.

摘　　要：Background:Esophageal cancer(EC)is a lethalmalignancy.The sociodemographic index(SDI)is a critical factor influencing the disease burden of EC.Risk factors,including alcohol use and diet,vary significantly by SDI level,affecting the disease outcomes.This study utilized the Global Burden of Disease Study 2021 database to determine the age-standardized mortality rates(ASMR)and age-standardized disability-adjusted life-year rates(ASDRs)for EC attributable to alcohol use and a diet low in vegetables across countries with different SDI.Methods:Data from the Global Burden of Disease Study 2021,covering from 1990 to 2021,were analyzed for 204 areas categorized into quintiles based on the SDI.Exposure levels for alcohol and vegetable intake were defined,and data were standardized using the global population structure to ensure comparability.Trend lines for the disease burden were plotted using R version 4.3.0(R Foundation for Statistical Computing,Vienna,Austria).Statistical analyses were conducted using Joinpoint 4.9.1.0(The Division of Cancer Control and Population Sciences,USA)regression to assess temporal trends in mortality and ASDRs,focusing on the annual percent change and average annual percent change across various SDI categories.Results:From 1990 to 2021,the ASMR and ASDR for EC decreased globally across all SDI levels and in both sexes.The areas with a middle SDI initially had the highest rates but experienced the fastest declines,falling below high-middle–SDI countries by 2021.The ASMRs attributable to alcohol use generally declined,except in low-middle–and low-SDI nations.The greatest rates among males and the total population were found in high-middle–SDI nations,whereas high-SDI nations had the highest rates among females.The ASMRs associated with a diet low in vegetables decreased in all areas.Conclusions:Despite the overall declining trend in the EC burden associated with alcohol use and diets low in vegetables,EC remains a significant global health concern.Strengthening the focus on key population

关 键 词：Esophageal cancer Global Burden of Disease Study 2021 Sociodemographic index Disease burden Joinpoint model 

分 类 号：R57[医药卫生—消化系统]