系统免疫炎症指数与脑卒中后抑郁的相关性分析  

Correlation analysis between systemic immune inflammation index and post-stroke depression

作　　者：李嘉庆[1] 刘竹韵 林凤燕 张琼莉 刘婉芬 Li Jiaqing;Liu Zhuyun;Lin Fengyan;Zhang Qiongli;Liu Wanfen(Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou,Guangdong 511400,China)

机构地区：[1]广东省中医院,广东广州511400

出　　处：《首都食品与医药》2025年第5期35-38,共4页Capital Food Medicine

摘　　要：目的 探讨系统免疫炎症指数(SII)与脑卒中后抑郁风险的相关性,为脑卒中患者的预后管理提供依据.方法 收集2011-2018年美国国家健康与营养调查(NHANES)中脑卒中患者数据,运用多因素Logistic回归分析SII与脑卒中后抑郁相关性,使用受限三次样条回归模型探讨两者间的剂量-反应关系.结果 共纳入713例脑卒中患者,脑卒中后抑郁发生率为22.86%.脑卒中患者总体SII中位数为423.69,上下四分位数分别为298.43和592.84,脑卒中后抑郁患者SII水平高于对照组,组间差异具有统计学意义(Z=-3.391,P<0.05).SII与脑卒中后抑郁风险呈正向线性关系(非线性:P=0.721).结论 SII升高是脑卒中后抑郁的独立危险因素,可以作为辅助诊断标志物,帮助改善脑卒中患者预后.Objective To investigate the association between the systemic immune-inflammation index(SII)and the risk of post-stroke depression,and to provide insights for the prognostic management of stroke patients.Methods Collect data on stroke patients from the National Health and Nutrition Examination Survey(NHANES)in the United States from 2011 to 2018,analyze the correlation between SII and post-stroke depression using multiple Logistic regression,and explore the dose-response relationship between the two using a limited cubic spline regression model.Results A total of 713 patients with stroke were included,and the incidence of post-stroke depression was 22.86%.The median SII score for all stroke patients was 423.69,with the lower and upper quartiles were 298.43 and 592.84,respectively.The SII level in patients with post-stroke depression was higher than that in the control group,and the difference between the groups was statistically significant(Z=-3.391,P<0.05).The results of RCS analysis indicated a positive linear relationship between SII and the risk of post-stroke depression(nonlinearity P=0.721).Conclusion An elevated SII is an independent risk factor for post-stroke depression and can serve as an auxiliary diagnostic marker for post-stroke depression,helping to improve the prognosis of patients with cerebral stroke.

关 键 词：系统免疫炎症指数 脑卒中 抑郁 横断面研究 

分 类 号：R749.13[医药卫生—神经病学与精神病学]