药用植物成分抗抑郁药理作用研究进展  

Research progress on antidepressant pharmacological effects of medicinal plant components

作　　者：杨仕琦 杨媛[1] 陈新利[1] 常伟宇 段明秀 陈丽元 吴晖[1] YANG Shiqi;YANG Yuan;CHEN Xinli;CHANG Weiyu;DUAN Mingxiu;CHEN Liyuan;WU Hui(Clinical Pharmacy Center,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院临床药学中心,昆明650032

出　　处：《中华中医药杂志》2025年第2期780-783,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金地区科学基金项目(No.41964007)。

摘　　要：临床上常用于治疗抑郁症的药物有帕罗西汀、文拉法辛、曲唑酮等,存在不良反应较多、停药后病情容易复发等问题,开发疗效显著且不良反应少的新型药物是治疗抑郁症面临的问题。药用植物活性成分治疗抑郁症具有多靶点、多途径的特点,为抑郁症治疗药物的开发提供了更多的选择。文章综述了具有抗抑郁作用的苯丙素类、黄酮类、皂苷类等药用植物活性成分及其作用机制,为进一步研究与临床应用提供参考。Commonly prescribed medications for depression included paroxetine,venlafaxine,and trazodone.However,these are many adverse reactions and patients frequently experienced relapse after discontinuing medication.The primary challenge in the treatment of depression lay in the development of new drugs that were highly effective with less side effects.The active components found in medicinal plants offered a multi-target and multi-pathway approach to addressing depression,potentially expanding the options for developing new treatment drugs.This paper provided a review of the active components of medicinal plants with anti-depressant effects,such as phenylpropanoids,flavonoids,and saponins,serving as a reference for further exploration into their mechanisms of action or potential clinical applications.

关 键 词：抑郁症 药用植物 活性成分 抗抑郁药 天然产物 

分 类 号：R74[医药卫生—神经病学与精神病学]