新型免疫检查点TIM-3在肿瘤研究中的趋势、热点及临床研究进展:基于文献计量分析  

Trends,frontiers,and clinical trials of TIM-3 in cancer research:a bibliometric analysis

作　　者：汪子书 乔宇 WANG Zishu;QIAO Yu(Department of Oncology,The First Affiliated Hospital of Bengbu Medical University,Bengbu Anhui 233004,China)

机构地区：[1]蚌埠医科大学第一附属医院肿瘤内科,安徽蚌埠233004

出　　处：《蚌埠医科大学学报》2025年第1期22-28,共7页Journal of Bengbu Medical University

基　　金：安徽省科研编制计划-科学研究项目-重大项目(2022AH040214);安徽省临床医学研究转化专项(202204295107020038)。

摘　　要：目的:探讨T细胞免疫球蛋白和黏蛋白结构域蛋白3(TIM-3)在肿瘤研究中的年发文量趋势、研究前沿及热点和临.床试验现状。方法:基于Web Of Science Core Collection数据库,利用Microsoft Excel、CiteSpace6.3.R1(Advanced)、VOSviewer,对TIM-3与肿瘤相关的427条数据进行文献计量分析。结果:TIM-3在肿瘤领域的相关研究逐年增加;TIM-3与其他免疫检查点在肿瘤中共表达;程序性死亡受体配体1(PD-L1)抗体和程序性死亡受体1(PD-1)治疗为TIM-3相关肿瘤研究较活跃的研究方向。结论:TIM-3与PD-1、PD-L1、LAG-3、CTLA-4、TIGHT等其他免疫检查点共表达与肿瘤预后有关;+TIM-3使CD8 T细胞、自然杀伤细胞、树突状细胞等免疫细胞耗竭,抑制抗肿瘤免疫;国内外尚无靶向TIM-3抗肿瘤药物上市,尽管有较多临床试验正在进行,但均处于临床前阶段。Objective:To investigate the annual publication trends,research frontiers and hotspots,and clinical trial status of T cell immunoglobulin and mucin domain-containing protein 3(TIM-3)in cancer research.Methods:By using Microsoft Excel,CiteSpace6.3.R1(Advanced)and VOSviewer,a bibliometric analysis was conducted on 427 articles involving TIM-3 related with tumor based on Web of Science Core Collection database.Results:The research on TIM-3 in cancer has been increasing each year.TIM-3 is co-expressed with other immune checkpoints in tumors.Programmed death receptor ligand 1(PD-L1)antibody and programmed death receptor 1(PD-1)therapy are active research directions in TIM-3-related tumor studies.Conclusions:The co-expression of TIM-3 with other immune checkpoints such as PD-1,PD-L1,LAG-3,CTLA-4,and TIGHT is associated with tumor+prognosis.TIM-3 induces exhaustion of immune cells such as CD8 T cells,natural killer cells,and dendritic cells,leading to inhibition of anti-tumor immunity.Currently,there are no approved TIM-3-targeted anti-cancer drugs available globally.Although numerous clinical trials are underway,they are still in the preclinical stage.

关 键 词：肿瘤 T细胞免疫球蛋白和黏蛋白结构域蛋白3 文献计量分析 

分 类 号：R73[医药卫生—肿瘤]