术前全身炎症反应指数联合改良衰弱指数对胃癌根治术后并发症的预测价值  

Predictive Value of Preoperative Systemic Inflammatory Response Index Combined with Modified Frailty Index for Complications after Radical Gastrectomy for Gastric Cancer

作　　者：顾宏[1] GU Hong(Rugao People's Hospital,Rugao,Jiangsu 226500,China)

机构地区：[1]如皋市人民医院,江苏如皋226500

出　　处：《转化医学杂志》2024年第11期1889-1893,共5页Translational Medicine Journal

基　　金：南通市科技局市级科技计划(指导性)(JCZ21150)。

摘　　要：目的研究术前全身炎症反应指数(SIRI)联合改良衰弱指数(mFI-11)对胃癌根治术后并发症的预测价值。方法回顾性分析如皋市人民医院2015年7月至2023年7月收治的150例胃癌患者的资料数据。150例患者均接受胃癌根治术治疗,其中术后有并发症者31例,记为观察组。无并发症者119例,记为对照组。对比两组患者的一般资料,分析患者胃癌根治术后并发症的影响因素,以及mFI-11联合SIRI对胃癌根治术后并发症的预测价值。结果观察组的ASA分级为Ⅲ~Ⅳ比例、术前白蛋白水平、mFI-11≥3分及SIRI≥1.3的比例高于对照组,手术时间长于对照组(P<0.05)。根据Logistic回归分析发现,ASA分级Ⅲ~Ⅳ级、术前白蛋白、手术时间、mFI-11≥3分及SIRI≥1.3均为患者胃癌根治术后并发症的危险因素(P<0.05)。根据ROC曲线分析发现,mFI-11联合SIRI对胃癌根治术后并发症的预测价值相对于二者单独预测更高,其中AUC为0.932,敏感度为95.24%,特异度为88.36%,95%CI为0.377~0.995。结论ASA分级Ⅲ~Ⅳ级、术前白蛋白、手术时间、mFI-11≥3分及SIRI≥1.3均为患者胃癌根治术后并发症的危险因素,且mFI-11联合SIRI对胃癌根治术后并发症的预测价值较高,有助于在临床上对患者的预后进行研判。Objective To study the predictive value of preoperative systemic inflammatory response index(SIRI)combined with modified frailty index(mFI-11)for complications after radical gastrectomy.Methods A retrospective analysis was conducted on the data of 150 gastric cancer patients admitted to Rugao People's Hospital from July 2015 to July 2023.All 150 patients underwent radical gastrectomy,among which 31 patients with postoperative complications were designated as the observation group,and 119 patients without complications were designated as the control group.The general information of the two groups was compared to analyze the influencing factors of postoperative complications and the predictive value of the combination of mFI-11 and SIRI for postoperative complications.Results The proportions of patients with ASA gradeⅢ-Ⅳ,preoperative albumin level,mFI-11≥3 points and SIRI≥1.3 in the observation group were higher than those in the control group,and the operation time was longer than that in the control group(P<0.05).According to the Logistic regression analysis,ASA gradeⅢ-Ⅳ,preoperative albumin,operation time,mFI-11≥3 points and SIRI≥1.3 were all risk factors for postoperative complications(P<0.05).According to the ROC curve analysis,the predictive value of the combination of mFI-11 and SIRI for postoperative complications was higher than that of either one alone,with an AUC of 0.932,a sensitivity of 95.24%,a specificity of 88.36%,and a 95%confidence interval(95%CI)of 0.377-0.995.Conclusion ASA gradeⅢ-Ⅳ,preoperative albumin,operation time,mFI-11≥3 points and SIRI≥1.3 are all risk factors for postoperative complications,and the combination of mFI-11 and SIRI has a high predictive value for postoperative complications,which is helpful for clinical prognosis assessment of patients.

关 键 词：术前 全身炎症反应指数 改良衰弱指数 胃癌根治术 并发症 预测价值 

分 类 号：R735.2[医药卫生—肿瘤]