脉搏血氧灌注指数联合血清bFGF对早产儿视网膜病变诊断价值及与病理分期的关系  

The Diagnostic Value of Pulse Oxygenation Perfusion Index Combined with Serum bFGF and Its Relationship with Pathological Stage of Retinopathy of Prematurity

作　　者：梅涛 刘滢 高慧萍 张琳 MEI Tao;LIU Ying;GAO Huiping;ZHANG Lin(Department of Pediatrics,Changzhou Maternal and Child Health Hospital,Changzhou,Jiangsu 213000,China)

机构地区：[1]常州市妇幼保健院儿科,江苏常州213000

出　　处：《转化医学杂志》2024年第11期1899-1903,共5页Translational Medicine Journal

基　　金：常州市青年人才科技项目(QN202131)。

摘　　要：目的研究脉搏血氧灌注指数(PI)联合血清碱性成纤维细胞生长因子(bFGF)对早产儿视网膜病变(ROP)诊断价值及与病理分期的关系。方法选择从2022年1月至2023年12月在常州市妇幼保健院就诊的103例ROP患儿进行研究,记作观察组。对视网膜病变患儿的病情严重程度实施分期,其中Ⅰ期26例,Ⅱ期40例,Ⅲ期23例,Ⅳ期14例。另选同期在常州市妇幼保健院分娩的健康胎儿100例作为对照组,对比2组一般资料,两组PI和血清bFGF水平,不同病理分期患儿的PI和血清bFGF水平,分析患儿的病理分期与PI及bFGF相关性,通过Logistic回归分析法分析影响ROP发生的危险因素,利用受试者工作特征曲线(ROC)分析PI和血清bFGF对ROP的诊断价值。结果观察组的体质量低于对照组(P<0.05),2组的性别和出生孕周,以及分娩方式和胎儿情况比较,差异无统计学意义(P>0.05)。观察组PI和血清bFGF水平低于对照组(P<0.05)。Ⅰ期患儿的PI和血清bFGF水平高于其他各期,Ⅲ、Ⅳ期患儿的PI和血清bFGF水平低于Ⅱ期,且Ⅳ期低于Ⅲ期(P<0.05)。Spearman法分析发现患儿的病理分期与PI及bFGF均呈负相关。Logistic回归分析发现,PI及bFGF是影响ROP发生的危险因素。PI和血清bFGF二者联合对ROP的诊断价值相比单独检测更高(Z=3.244、3.208,P=0.005、0.008),其中AUC为0.948,灵敏度为96.27%,特异度为84.18%。结论PI联合血清bFGF对ROP患儿诊断价值较高,且与病理分期具有紧密的关系,能够较好地诊断患儿的病理分期,值得临床关注。Objective To study the diagnostic value of pulse oxygenation perfusion index(PI)combined with serum basic fibroblast growth factor(bFGF)in the diagnosis of retinopathy of prematurity(ROP)and its relationship with pathological stage.Methods A total of 103 children with ROP who visited Changzhou Maternal and Child Health Hospital from January 2022 to December 2023 were selected for study,and they were recorded as the observation group.The severity of ROP was staged as follows:26 cases in stage I,40 cases in stageⅡ,23 cases in stageⅢ,14 cases in stageⅣ.An additional 100 healthy fetuses delivered during the same period at the hospital were selected as the control group.The general data of the two groups were compared,and PI and serum bFGF levels were assessed.The relationship between different pathological stages and PI,as well as serum bFGF levels,was analyzed.Logistic regression was used to evaluate the risk factors for the occurrence of ROP,and ROC curve analysis was performed to determine the diagnostic value of PI and serum bFGF for ROP.Results The body weight of the observation group was lower than that of the control group(P<0.05).No significant differences were observed between the two groups in terms of gender,gestational age,delivery mode,and fetal condition(P>0.05).The levels of PI and serum bFGF in the observation group were lower than those in the control group(P<0.05).In stage I,the levels of PI and serum bFGF were higher than those in the other stages.The levels of PI and serum bFGF in stageⅢandⅣwere lower than those in stageⅡ,with stageⅣbeing lower than stageⅢ(P<0.05).Spearman's analysis found a negative correlation between the pathological stage and both PI and bFGF.Logistic regression revealed that PI and bFGF were risk factors influencing the occurrence of ROP.The combination of PI and serum bFGF had a higher diagnostic value for ROP compared to individual testing(Z=3.244,3.208;P=0.005,0.008),with an AUC of 0.948,sensitivity of 96.27%,and specificity of 84.18%.Conclusion PI combined

关 键 词：脉搏血氧灌注指数 血清 BFGF 早产儿视网膜病变 诊断价值 病理分期 

分 类 号：R774.1[医药卫生—眼科]