联合超声造影与肿瘤标志物检测在肝癌射频消融术后疗效评估中的应用  

Analysis of Factors Associated with the Occurrence of Combined Hypothyroidism in Pregnancy and Implementation of Intervention Measures:A Logistic Study

作　　者：刘娉婷 陈海妮 王薪越 张渝科 LIU Pingting;CHEN Haini;WANG Xinyue;ZHANG Yuke(Department of Ultrasonography,The 958th Hospital of Chinese People's Liberation Army,Chongqing 400020,China)

机构地区：[1]陆军第九五八医院超声诊断科,重庆400020

出　　处：《转化医学杂志》2024年第11期1962-1964,1968,共4页Translational Medicine Journal

基　　金：2013-2-305新型双套管对肠瘁患者影响的临床研究。

摘　　要：目的探讨肝细胞癌(HCC)患者射频消融术后预后的影响因素,比较术后肿瘤标志物AFP、PIVKA-II与超声造影对肝癌疗效评估的效能。方法选取2020年5月至2023年5月在陆军第九五八医院接受射频消融术治疗的肝细胞癌患者114例,分为预后良好组和预后不良组,各57例。术后6个月随访,进行超声造影和肿瘤标志物检测。通过统计分析比较两组患者术后肿瘤消融率及甲胎蛋白(AFP)和异常凝血酶原(PIVKA-Ⅱ)的变化,采用受试者工作特征曲线ROC评估肿瘤标志物与超声造影对肝癌诊断的效能。结果预后良好组的肿瘤消融率明显高于预后不良组(85.9%vs 56.1%,P<0.001)。术后6个月,预后良好组AFP和PIVKA-II水平明显下降(P<0.001),而预后不良组无明显下降。联合超声造影与肿瘤标志物检测对肝癌诊断的灵敏度和特异度明显高于单一检测方法(联合检测灵敏度88.76%,特异度93.84%)。结论肝细胞癌患者射频消融术后联合肿瘤标志物与超声造影评估方法在诊断和疗效判断中具有较高的灵敏度和特异度。Objective To explore the factors affecting the prognosis of patients with hepatocellular carcinoma(Hepatocellular Carcinoma,HCC)after radiofrequency ablation,and to compare the efficacy of postoperative tumor markers Alpha-fetoprotein(Alpha-fetoprotein,AFP),Protein Induced by Vitamin K Absence or Antagonist-II(Protein Induced by Vitamin K Absence or Antagonist-II,PIVKA-II)and ultrasonography in assessment of HCC efficacy.Methods 114 patients with HCC who underwent radiofrequency ablation at The 958th Hospital of Chinese People's Liberation Army from May 2020 to May 2023 were selected and divided into a good prognosis group and a poor prognosis group,with 57 cases in each group.The patients were followed up at 6 months postoperatively with ultrasonography and tumor marker tests.The efficacy of tumor markers and ultrasonography in the diagnosis of HCC was assessed by statistical analysis comparing the postoperative tumor ablation rate and the changes of AFP and PIVKA-II in the two groups,and by using the ROC curve.Results The tumor ablation rate in the good prognosis group was significantly higher than that in the poor prognosis group(85.9%vs 56.1%,P<0.001).At 6 months postoperatively,AFP and PIVKA-II levels decreased significantly in the good prognosis group(P<0.001),whereas there was no significant decrease in the poor prognosis group.The sensitivity and specificity of combined ultrasonography and tumor marker detection for the diagnosis of HCC were significantly higher than that of single detection methods(88.76%sensitivity and 93.84%specificity for combined detection).Conclusion The combined tumor marker and ultrasonography assessment method after radiofrequency ablation in patients with HCC has high sensitivity and specificity in diagnosis and efficacy determination.

关 键 词：肝癌 射频消融 超声造影 肿瘤标志物 疗效评估 

分 类 号：R735.7[医药卫生—肿瘤]