甲泼尼龙琥珀酸钠联合手术治疗对急性脊髓损伤患者运动功能和神经炎症的影响  

The Effect of Methylprednisolone Sodium Succinate Combined with Surgical Treatment on Motor Function and Neuroinflammation in Patients with Acute Spinal Cord Injury

作　　者：吴晓燕 冯晓军 WU Xiaoyan;FENG Xiaojun(Department of Rehabilitation Medicine,Xishan People's Hospital,Wuxi,Jiangsu 214000,China;Department of Orthopedics,Xishan People's Hospital,Wuxi,Jiangsu 214000,China)

机构地区：[1]无锡市锡山人民医院康复医学科,江苏无锡214000 [2]无锡市锡山人民医院骨科,江苏无锡214000

出　　处：《转化医学杂志》2024年第11期2043-2045,共3页Translational Medicine Journal

基　　金：无锡市卫生健康委员会科研项目(M202357)。

摘　　要：目的探讨甲泼尼龙琥珀酸钠(MPSS)联合手术治疗对急性脊髓损伤(ASCI)患者运动功能和神经炎症的影响。方法选取2020年1月至2023年12月无锡市锡山人民医院收治的100例ASCI患者为研究对象,将其随机分为对照组(仅手术治疗)与试验组(MPSS联合手术治疗),比较治疗后2组ASCI患者的神经功能及炎症因子变化情况。结果术前对照组与试验组脊髓损伤神经的感觉功能和运动功能评分比较差异均无统计学意义(P均>0.05);术后3个月,2组患者脊髓损伤神经的感觉功能和运动功能评分比较差异均具有统计学意义(P均<0.01)。术后1周,试验组肿瘤坏死因子α(TNF-α)显著低于对照组(P<0.01);对照组术前与术后TNF-α比较差异无统计学意义(P>0.05);试验组术前与术后TNF-α比较差异具有统计学意义(P<0.01)。结论MPSS联合手术治疗ASCI可有效抑制促炎因子的释放,减轻神经炎症反应,其在ASCI治疗中具有显著优势。Objective To explore the effect of methylprednisolone sodium succinate(MPSS)combined with surgical treatment on motor function and neuroinflammation in patients with acute spinal cord injury(ASCI).Methods A total of 100 patients with ASCI admitted to Xishan People's Hospital of Wuxi City from January 2020 to December 2023 were selected as the research subjects.They were randomly divided into a control group(treated with surgery only)and an experimental group(treated with MPSS combined with surgery).The changes in neurological function and inflammatory factors of the two groups of ASCI patients after treatment were compared.Results There were no statistically significant differences in the sensory and motor function scores of spinal cord injury nerves between the control group and the experimental group before surgery(P>0.05 for all).Three months after surgery,there were statistically significant differences in the sensory and motor function scores of spinal cord injury nerves between the two groups(P<0.01).One week after surgery,the level of tumor necrosis factor-α(TNF-α)in the experimental group was significantly lower than that in the control group(P<0.01).There was no statistically significant difference in TNF-αlevels between pre-and post-operation in the control group(P>0.05),while there was a statistically significant difference in TNF-αlevels between pre-and post-operation in the experimental group(P<0.01).Conclusion MPSS combined with surgery for the treatment of ASCI can effectively inhibit the release of pro-inflammatory factors and reduce the neuroinflammatory response.It has significant advantages in the treatment of ASCI.

关 键 词：急性脊髓损伤 甲泼尼龙琥珀酸钠 手术治疗 运动功能 神经炎症 

分 类 号：R744[医药卫生—神经病学与精神病学]