节律基因在结直肠癌发生发展和时辰疗法中的研究进展  

Research progress of circadian genes in the occurrence,development and chronotherapy of colorectal cancer

作　　者：詹海峰 谭子煊 王文学 耿嘉蔚 Zhan Haifeng;Tan Zixuan;Wang Wenxue;Geng Jiawei(Department of Infectious Diseases and Liver Diseases,Affiliated Hospital of Kunming University of Science and Technology,First People's Hospital of Yunnan Province,Kunming 650500,China)

机构地区：[1]昆明理工大学附属医院/云南省第一人民医院感染性疾病及肝病科,昆明650500

出　　处：《国际肿瘤学杂志》2025年第1期60-64,共5页Journal of International Oncology

基　　金：国家自然科学基金(82360395)。

摘　　要：近年来,研究发现节律基因的异常表达与结直肠癌发生风险及病程进展密切相关。此外,基于昼夜节律理论的时辰疗法在结直肠癌临床治疗中呈现了一定的效果,但仍存在很大的局限性。因此,明确节律基因在结直肠癌发生发展中的作用机制十分重要,或可为时辰疗法的临床应用提供理论依据。In recent years,studies have found that the abnormal expression of rhythm genes is closely related to the risk of occurrence and the progression of the disease course of colorectal cancer.In addition,chronotherapy based on the circadian rhythm theory has shown certain effects in the clinical treatment of colorectal cancer,but there are still great limitations.Therefore,it is very important to clarify the mechanism of action of rhythm genes in the occurrence and development of colorectal cancer,which may provide a theoretical basis for the clinical application of chronotherapy.

关 键 词：昼夜节律 结直肠肿瘤 时钟基因 

分 类 号：R73[医药卫生—肿瘤]