替罗非班联合低分子肝素治疗急性穿支动脉型脑梗死的临床效果  

Clinical effect of tirofiban combined with low molecular weight heparin in the treatment of acute perforator artery cerebral infarction

作　　者：何志成 黄汉宁[2] HE Zhicheng;HUANG Hanning(Department of Critical Care Medicine,Gaozhou People's Hospital,Gaozhou 525200,China;Department of Neurology,Gaozhou People's Hospital,Gaozhou 525200,China)

机构地区：[1]高州市人民医院重症医学科,广东高州525200 [2]高州市人民医院神经内科,广东高州525200

出　　处：《延边大学医学学报》2025年第1期41-44,共4页Journal of Medical Science Yanbian University

基　　金：茂名市科技计划项目(编号:2023003)。

摘　　要：目的:探究替罗非班联合低分子肝素治疗急性穿支动脉型脑梗死(PACI)的临床效果。方法:选取高州市人民医院于2023年4月至2024年9月收治的102例PACI患者,运用抽签法分为试验组及对照组,每组各51例。对照组采用低分子肝素治疗,试验组在采用低分子肝素治疗的基础上加用替罗非班治疗。观察两组治疗后的临床疗效、神经功能缺损评分量表(CSS)评分、日常生活活动量表(ADL)评分、美国国立卫生研究院卒中量表(NIHSS)评分、不良反应发生情况。结果:试验组治疗的总有效率为90.20%,高于对照组的74.51%(P<0.05);治疗后,试验组患者的NIHSS、CSS评分低于对照组(P<0.05),ADL评分高于对照组(P<0.05);试验组不良反应发生率为19.61%,高于对照组的7.84%,但差异无统计学意义(P>0.05)。结论:替罗非班联合低分子肝素治疗PACI的临床效果确切,可加快神经功能的修复,提高日常生活活动能力。Objective:To explore the clinical effect of tirofiban combined with low molecular weight heparin in the treatment of acute perforator artery cerebral infarction(PACI).Methods:A total of 100 PACI patients admitted to Gaozhou People's Hospital from April 2023 to September 2024 were selected and divided into an experimental group and a control group by drawing lots,with 51 cases in each group.The control group was treated with low molecular weight heparin,and the experimental group was treated with Tirofiban on the basis of low molecular weight heparin.The clinical efficacy,China Stroke Scale(CSS)score,Activities of Daily Living Scale(ADL)score,National Institutes of Health Stroke Scale(NIHSS)score and adverse reactions were observed in the two groups after treatment.Results:The total effective rate of the experimental group was 90.20%,which was higher than the control group's 74.51%(P<0.05).After treatment,the NIHSS and CCS scores of the experimental group were lower than those of the control group(P<0.05),and the ADL scores were higher than those of the control group(P<0.05).The incidence of adverse reactions in the experimental group was 19.61%,which was higher than the control group's 7.84%,but there was no significant difference(P>0.05).Conclusion:Tirofiban combined with low molecular weight heparin in the treatment of PACI has definite clinical effect,which can accelerate the repair of nerve function and improve the ability of daily living activities.

关 键 词：急性穿支动脉型脑梗死 替罗非班 低分子肝素 神经功能 日常生活活动能力 

分 类 号：R743.3[医药卫生—神经病学与精神病学]