美沙拉秦联合康复新液治疗溃疡性结肠炎的临床疗效  

Clinical Efficacy of Mesalazine combined with Kangfuxin Liquid in Ulcerative Colitis

作　　者：李亚 荣金霞 LI Ya;RONG Jin-Xia(Department of Diagnostics,Shangqiu Medical College,Shangqiu 476000,China;Department of Gastroenterology,The Third People's Hospital of Shangqiu,Shangqiu 476000000,China)

机构地区：[1]商丘医学高等专科学校诊断学教研室,河南商丘476000 [2]商丘市第三人民医院消化内科,河南商丘476000

出　　处：《中国药物经济学》2025年第1期51-55,共5页China Journal of Pharmaceutical Economics

摘　　要：目的探讨美沙拉秦联合康复新液治疗溃疡性结肠炎(UC)的临床疗效。方法选取2021年8月至2024年3月商丘市第三人民医院收治的94例UC患者为研究对象,按照治疗方法不同分为观察组(常规治疗+美沙拉秦肠溶片联合康复新液,47例)和对照组(常规治疗+美沙拉秦肠溶片,47例)。比较两组患者临床疗效、炎症因子、凝血功能、肠道菌群、不良反应情况。结果治疗前两组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)、纤维蛋白原(Fib)、凝血酶原时间(PT)、平均血小板体积(MPV)、血小板计数(PLT)及粪肠球菌、大肠杆菌、乳酸杆菌、双歧杆菌菌群数量比较,差异不显著(P>0.05);治疗后,相较于对照组,观察组治疗有效率更高,TNF-α、IL-6、hs-CRP、IL-1β、Fib、PLT水平更低,PT、MPV水平更高,粪肠球菌、大肠杆菌菌群数量更低,乳酸杆菌、双歧杆菌菌群数量更高,不良反应发生率更低,差异均显著(P<0.05)。结论美沙拉秦联合康复新液治疗UC效果显著,能够有效抑制炎症反应,改善血液高凝状态,调节肠道菌群失衡,减少不良反应发生。Objective To explore the clinical effect of mesalazine combined with Kangfuxin solution in the treatment of ulcerative colitis(UC).Methods A total of 94 patients with UC admitted to the Third People's Hospital of Shangqiu City from August 2021 to March 2024 were selected as the study objects,and were divided into observation group(conventional treatment+mesalazine enteric-coated tablets combined with Kangfu Xin solution,47 cases)and control group(conventional treatment+mesalazine enteric-coated tablets,47 cases)according to different treatment methods.The clinical efficacy,inflammatory factors,coagulation function,intestinal flora and adverse reactions were compared between the two groups.Results There were no significant difference tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP),interleukin-1β(IL-1β),fibrinogen(Fib),prothrombin time(PT),mean platelet volume(MPV),platelet count(PLT),enterococcus faecalis and large intestine,the number of bacillus,lactobacillus and bifidobacterium in the two groups before treatment(P>0.05).After treatment,compared with the control group,the treatment effectiveness in the observation group was higher,the levels of TNF-α,IL-6,hs-CRP,IL-1β,Fib and PLT were lower,the levels of PT and MPV were higher,the number of Enterococcus faecalis and Escherichia coli was lower,the number of lactobacillus and bifidobacterium was higher,and the incidence of adverse reactions was lower.The differences were significant(P<0.05).Conclusion Mesalazine combined with Kangfuxin solution has a significant effect in the treatment of UC,which can effectively inhibit inflammation,improve blood hypercoagulability,regulate intestinal flora imbalance,and reduce adverse reactions.

关 键 词：溃疡性结肠炎 美沙拉秦 康复新液 临床疗效 

分 类 号：R574.1[医药卫生—消化系统] R975[医药卫生—内科学]