马来酸曲美布汀联合雷贝拉唑治疗胃食管反流性咳嗽的临床效果  

Clinical Efficacy of Trimebutine Maleate and Rabeprazole in the Treatment of Gastroesophageal Reflux Cough

作　　者：段霞 张景波 段庆琳 DUAN Xia;ZHANG Jing-Bo;DUAN Qing-Lin(Department of Spleen,Stomach and Hepatobiliary Zhangqiu District Hospital of Traditional Chinese Medicine,Jinan 250200,China;Department of Cardiothoracic Surgery,Zhangqiu District Hospital of Traditional Chinese Medicine,Jinan 250200,China;Endoscopy Center,the Second Rehabilitation Hospital of Shandong Province,Tai'an 271000,China)

机构地区：[1]济南市章丘区中医医院脾胃肝胆科,济南250200 [2]济南市章丘区中医医院心胸外科,济南250200 [3]山东省第二康复医院内镜中心,山东泰安271000

出　　处：《中国药物经济学》2025年第1期66-69,共4页China Journal of Pharmaceutical Economics

基　　金：济南市卫生健康委员会计划项目(2022-中-43)。

摘　　要：目的探讨胃食管反流性咳嗽(GERC)患者采用马来酸曲美布汀联合雷贝拉唑治疗的临床效果。方法选取2020年8月至2023年8月济南市章丘区中医医院收治的GERC患者102例,按随机数字表法分为观察组(n=51)和对照组(n=51)。对照组给予雷贝拉唑治疗,观察组给予马来酸曲美布汀联合雷贝拉唑治疗,比较两组临床疗效、咳嗽症状评分、胃食管反流病问卷(GerdQ)评分、胃肠激素水平及不良反应。结果观察组治疗有效率为98.04%,较对照组的84.31%更高(P<0.05);治疗后两组日间及夜间咳嗽症状评分降低(P<0.05),观察组较对照组更低(P<0.05);治疗后两组GerdQ评分下降(P<0.05),观察组较对照组更低(P<0.05);治疗后两组胃泌素(GAS)水平升高(P<0.05),观察组GAS水平较对照组更高(P<0.05);观察组不良反应发生率3.92%与对照组7.84%比较,差异无统计学意义(P>0.05)。结论GERC患者采用马来酸曲美布汀联合雷贝拉唑治疗具有较高的临床疗效,可有效缓解咳嗽症状,降低GerdQ评分,改善胃肠激素水平,且不会增加不良反应。Objective To explore the clinical effect of trimebutin maleate combined with rabeprazole in the treatment of gastroesophageal reflux cough(GERC).Methods A total of 102 GERC patients admitted to Zhangqiu District Hospital of Traditional Chinese Medicine in Jinan City from August 2020 to August 2023 were selected and divided into observation group(n=51)and control group(n=51)according to random number table method.The control group was treated with rabeprazole,and the observation group was treated with trimebutin maleate combined with rabeprazole.The clinical efficacy,cough symptom score,GerdQ score,gastrointestinal hormone level and adverse reactions of the two groups were compared.Results The effective rate of observation group was 98.04%,which was higher than that of control group(84.31%)(P<0.05).After treatment,the scores of daytime and night cough symptoms in both groups were lower(P<0.05),and those in observation group were lower than those in control group(P<0.05).After treatment,the GerdQ score of the two groups decreased(P<0.05),and the observation group was lower than the control group(P<0.05).After treatment,gastrin(GAS)level of the two groups was increased(P<0.05),and GAS level of the observation group was higher than that of the control group(P<0.05).The incidence of adverse reactions in the observation group was 3.92%compared with 7.84%in the control group(P>0.05).Conclusion The combination therapy of trimebutine maleate and rabeprazole have high clinical effect on GERC patients,which can effectively alleviate cough symptoms,reduce GerdQ scores,improve gastrointestinal hormone levels,and do not increase adverse reactions.

关 键 词：马来酸曲美布汀 雷贝拉唑 胃食管反流性咳嗽 临床效果 

分 类 号：R573.7[医药卫生—消化系统] R975[医药卫生—内科学]