异甘草酸镁对原发性肝癌术后肝损伤的保护作用及机制  

Protective Effect and Mechanism of Magnesium Isoglycyrrhizinate on Postoperative Liver Injury in Patients with Primary Liver Cancer

作　　者：逯泽林 曹春远[2] LUZe-Lin;CAO Chun-Yuan(Clinical School of Changchun University of Traditional Chinese Medicine,Changchun 130000,China;Department of Hepatobiliary Pancreatic Surgery,Jilin Provincial People's Hospital,Changchun 130000,China)

机构地区：[1]长春中医药大学临床医学院,长春130000 [2]吉林省人民医院肝胆胰外科,长春130000

出　　处：《中国药物经济学》2025年第1期77-80,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨异甘草酸镁对原发性肝癌患者肝动脉化疗栓塞术(TACE)后肝损伤的保护作用及机制。方法选取2021年4月至2024年4月于吉林省人民医院接受TACE治疗的原发性肝癌患者98例,按随机数字表法分为对照组与观察组,各49例。对照组患者在TACE前1 d、后3 d分别使用还原型谷胱甘肽注射液、维生素C注射液,观察组在对照组基础上于相同时间点静脉滴注异甘草酸镁注射液。比较两组患者肝功能指标、炎症因子、氧化应激指标水平,以及治疗期间药物相关不良反应发生情况。结果术后1周,观察组丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、总胆红素(TBIL)水平较对照组低(P<0.05);观察组肿瘤坏死因子α(TNF-α)、核因子κB(NF-κB)、白细胞介素-6(IL-6)水平较对照组低(P<0.05);观察组丙二醛(MDA)水平低于对照组(P<0.05),超氧化物歧化酶(SOD)水平较对照组高(P<0.05)。治疗开始至术后1周内,两组患者均未出现明显恶心呕吐、肝炎、发热、感染等不良反应。结论异甘草酸镁加入原发性肝癌患者TACE后的保肝方案中,可积极优化肝功能,可能与其抑制炎症反应、减轻氧化应激的作用机制相关。Objective To explore the protective effect and mechanism of magnesium isoglycyrrhizinate on liver injury after hepatic artery chemoembolization(TACE)in patients with primary liver cancer.Methods Ninety-eight patients with primary liver cancer who received TACE treatment in Jilin Provincial People's Hospital from April 2021 to April 2024 were selected and divided into control group and observation group according to random number table method,with 49 cases in each group.The control group received reduced glutathione injection and vitamin C injection 1 day before and 3 days after TACE,respectively,and the observation group received magnesium isoglycyrrhizinate injection intravenously at the same time point on the basis of the control group.The levels of liver function indexes,inflammatory factors,oxidative stress indexes and drug-related adverse reactions during treatment were compared between the two groups.Results One week after operation,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and total bilirubin(TBIL)in observation group were lower than those in control group(P<0.05).The levels of tumor necrosis factorα(TNF-α),nuclear factorκB(NF-κB)and interleukin-6(IL-6)in observation group were lower than those in control group(P<0.05).The level of malondialdehyde(MDA)in observation group was lower than that in control group(P<0.05),and the level of superoxide dismutase(SOD)was higher than that in control group(P<0.05).No adverse reactions such as nausea,vomiting,hepatitis,fever and infection occurred in both groups from the beginning of treatment to one week after surgery.Conclusion Adding magnesium isoglycyrrhizinate to the liver protection regimen after TACE in patients with primary liver cancer can actively optimize the liver function of the patients,which may be related to the mechanism of inhibiting inflammation and alleviating oxidative stress.

关 键 词：原发性肝癌 异甘草酸镁 肝损伤 炎症因子 氧化应激 

分 类 号：R735.7[医药卫生—肿瘤] R975[医药卫生—临床医学]