不同药物治疗方案对诺如病毒感染性腹泻患者预后的影响  

Effect of Different Drug Treatment Regimens on Prognosis of Patients with Norovirus Infectious Diarrhea

作　　者：唐琪 TANG Qi(Department of Infectious Diseases,Beijing Millennium Temple Hospital,Bejjing 100036,China)

机构地区：[1]北京市世纪坛医院感染科,北京100036

出　　处：《中国药物经济学》2025年第1期101-104,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨不同药物治疗方案对诺如病毒(NV)导致感染性腹泻(ID)患者预后的影响。方法选取2022年9月至2023年10月北京市世纪坛医院收治的85例NV导致ID患者作为研究对象,按随机数字表法分为对照组(n=42例)与观察组(n=43例)。对照组予以蒙脱石散+酪酸梭菌治疗,观察组实施蒙脱石散+消旋卡多曲治疗。比较两组治疗总有效率、临床症状改善时间以及降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数(WBC)水平。结果观察组治疗总有效率为97.67%,明显高于对照组的76.19%(P<0.05);观察组大便性状恢复、退热、止泻及呕吐、腹痛消失时间均明显短于对照组(P<0.05);治疗后观察组PCT、CRP水平明显低于对照组(P<0.05),WBC水平明显高于对照组(P<0.05)。结论对NV导致ID患者实施蒙脱石散+消旋卡多曲治疗效果更显著,不仅能够促进临床症状快速缓解,还可有效降低炎症指标水平。Objective To investigate the effect of different drug therapy on the prognosis of patients with ID caused by norovirus(NV)To analyze the prognostic effects of different treatment regimens on children with Norovirus(NV)causing infectious diarrhea(ID).Methods 85 cases of NV-induced ID were analyzed.Eighty-five children with NV-induced ID,all from September 2022-October 2023,were divided into 2 groups according to the randomized numeric table method:the reference group(n=42)was treated with montelukast+clostridium typhimurium,and the observation group(n=43)was treated with montelukast+calcitriol,to analyze the total effective rate of the treatment in the 2 groups,The total effective rate of treatment,recovery time of clinical symptoms,and levels of procalcitoninogen(PCT),C-reactive protein(CRP)and white blood cells(WBC)were analyzed in the two groups.Results The total effective rate of treatment in the observation group was 97.67%,which was significantly higher than that of the reference group,which was 76.19%(P<0.05);the time for the recovery of fecal symptoms,fever,diarrhea,vomiting,and the disappearance of abdominal pain in the observation group was significantly shorter than that of the reference group(P<0.05);the levels of PCT and CRP in the observation group were significantly lower than that of the reference group after the treatment and the level of WBC was significantly higher than that of the reference group(P<0.05).Conclusion NV causes ID children to implement montelukast+Cardotril treatment effect is more significant,not only can promote the rapid recovery of clinical symptoms,but also effectively reduce the level of inflammatory factors.

关 键 词：蒙脱石散 酪酸梭菌 消旋卡多曲 诺如病毒 感染性腹泻 炎症指标 

分 类 号：R574.5[医药卫生—消化系统] R975[医药卫生—内科学]