徐州市体检人群玻璃膜疣的危险因素探究  

Exploring on the risk factors of drusen in the physical examination population in Xuzhou City

作　　者：郑黎 李敏 胡斌 肖立顺 沈桂芳 沈培璞 常明星 ZHENG Li;LI Min;HU Bin;XIAO Lishun;SHEN Guifang;SHEN Peipu;CHANG Mingxing(School of Public Health,Xuzhou Medical University,Xuzhou,Jiangsu 221004,China;不详)

机构地区：[1]徐州医科大学公共卫生学院,江苏徐州221004 [2]徐州医科大学附属医院健康管理中心

出　　处：《医学动物防制》2025年第4期322-329,共8页Journal of Medical Pest Control

基　　金：江苏省研究生科研与实践创新项目(SJCX23_1407)。

摘　　要：目的探讨2022年在徐州市某医院体检的人群中玻璃膜疣的患病现状及发病危险因素,为控制该病的发生发展提供依据。方法本研究采用回顾性设计,选取2022年1月至12月在徐州医科大学附属某医院健康管理中心进行体检并参与眼底照相检测的受检者,收集并比较患玻璃膜疣人群与未患人群基线资料,采用占比对分类变量进行描述,采用χ^(2)检验、t检验进行组间比较。采用多因素logistic回归分析分析导致玻璃膜疣的危险因素,并与广义线性混合模型结果进行比较,后应用限制性立方样条模型分析各危险因素与玻璃膜疣发病的趋势关系。结果本研究选取的561例受检者中,251例(44.74%)患有玻璃膜疣,将年龄和血小板分布宽度作为随机截距,考虑尿酸碱度、总胆汁酸、总胆红素等连续变量的随机斜率,结果显示,高血压病史(OR=2.076,P=0.020)、尿蛋白(OR=24.685,P=0.010)、总蛋白(OR=0.911,P=0.008)、体质指数(BMI)(OR=2.054,P=0.019)、尿白细胞(OR=0.975,P=0.004)均与玻璃膜疣的发生独立相关,且血小板分布宽度作为随机因子,是玻璃膜疣发病的危险因素。结论高血压病史、尿白细胞、尿蛋白、总蛋白等因素均提示玻璃膜疣的发病风险,应加强对高血压等重点人群的宣传干预工作,预防徐州市玻璃膜疣的发生和发展。Objective To investigate the prevalence and risk factors of drusen in a population examined at a hospital in Xuzhou City in 2022,and to provide a basis for controlling the occurrence and development of the disease.Methods In this study,a retrospective design was used to select the subjects who underwent physical examination and participated in fundus photographic examination at the health management center of a hospital affiliated to Xuzhou Medical University from January to December 2022.Baseline data were collected and compared between people who had drusen and those who did not.Categorical variables were described using percentages,and Chi-square test and t-test were used for comparison between groups.Multifactorial logistic regression was used to analyze the risk factors responsible for drusen and compared with the results of a generalized linear mixed model.Then the relationship between each risk factor and the trend in the development of drusen was analyzed by applying a restricted cubic spline model.Results Of the 561 subjects selected in this study,251(44.74%)had drusen.Taking age and platelet distribution width as random intercept and considering the random slopes of continuous variables such as urinary pH value,total bile acid,and total bilirubin.The results showed that history of hypertension(OR=2.076,P=0.020),urinary protein(OR=24.685,P=0.010),total protein(OR=0.911,P=0.008),body mass index(BMI)(OR=2.054,P=0.019),and urinary leukocyte(OR=0.975,P=0.004)were all independently associated with the development of drusen.The platelet distribution width,as a random view factor,was a risk factor for the incidence of drusen.Conclusion Factors such as history of hypertension,urinary leukocytes,urinary proteins,and total proteins are suggestive of the risk of drusen.Publicity interventions should be strengthened key populations such as those with hypertension to prevent the occurrence and development of drusen in Xuzhou City.

关 键 词：玻璃膜疣 危险因素 广义线性混合模型 LOGISTIC回归 

分 类 号：R776.4[医药卫生—眼科]