母胎交互调控囊胚激活机制的研究进展  

Research progress of regulating the blastocyst activation with maternal-fetal communication

作　　者：李凯茜 赵晓丽 徐佳淇 江楠 夏天[1] LI Kai-xi;ZHAO Xiao-li;XU Jia-qi;JIANG Nan;XIA Tian(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381)

机构地区：[1]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津300381

出　　处：《生殖医学杂志》2025年第3期398-404,共7页Journal of Reproductive Medicine

基　　金：国家自然科学基金(82205172)。

摘　　要：良好的母胎交互是胚胎成功植入的重要前提。在胚胎植入过程中,囊胚与子宫内膜协同发育,通过调节细胞外囊泡的释放和摄取、经典Wnt信号通路等信号通路活性以及整合素、L-选择素和肝素结合样表皮生长因子(HB-EGF)等信号分子的特异性表达等多种方式实现精准交流,促进囊胚的高细胞活性、细胞代谢和增殖,进而调控囊胚激活,使之获得黏附、侵入和植入能力。母胎对话异常影响囊胚激活,是导致胚胎种植失败的重要病理因素。本文从多个方面对母胎交互调控囊胚激活的分子机制进行阐述,以期为理解反复种植失败(RIF)的病理机制提供新的视角,也为临床优化IVF-ET妊娠结局提供潜在治疗策略。The intimate maternal-fetal communication between the endometrium and blastocyst serves as a crucial prerequisite for successful embryo implantation.During the embryo implantation process,the blastocyst and endometrium develop synergistically,regulating the release and uptake of extracellular vesicles,the activity of canonical Wnt signaling pathway,etc.,and the specific expression of molecules such as integrins,L-selectins,and heparin-binding epidermal growth factors(HB-EGF)and so on.Through these various mechanisms,they achieve precise and orchestrated communication.Their interaction enhances the blastocyst’s cellular activity,metabolism and proliferation,thereby controls its activation and facilitates the development of adhesion,invasion,and implantation capabilities.Disrupted maternal-fetal communication can negatively impact blastocyst activation,so it is a significant factor contributing to failed embryo implantation.This review delves into the molecular mechanisms underlying maternal-fetal communication in regulating blastocyst activation,offering a fresh perspective on the pathological processes involved in recurrent implantation failure(RIF).Additionally,it proposes potential therapeutic approaches for improving outcomes in clinical IVF-ET procedures.

关 键 词：囊胚激活 母胎交互 胚胎植入 子宫内膜容受性 细胞外囊泡 

分 类 号：R711.6[医药卫生—妇产科学]