动脉化疗栓塞联合射频消融治疗肝癌自发性破裂出血的效果研究  

Study on the Efficacy of Arterial Chemotherapy Embolization Combined with Radiofrequency Ablation in the Treatment of Spontaneous Rupture and Bleeding in Hepatocellular Carcinoma

作　　者：何理军 张瑜 吴行廷 HE Lijun;ZHANG Yu;WU Xingting(Catheter Room of Nanping Second Hospital,Nanping 354200,China)

机构地区：[1]南平市第二医院导管室,福建南平354200

出　　处：《中华灾害救援医学》2025年第1期31-35,共5页Chinese Journal of Disaster Medicine

基　　金：南平市自然科学基金联合资助项目(N2021J046)。

摘　　要：目的 探讨对肝癌自发性破裂出血患者实施急诊介入治疗后的治疗效果及应用价值。方法 选取2021年6月至2024年6月南平市第二医院收治的63例肝癌自发性破裂出血患者的临床资料进行回顾性分析。根据手术方法的不同,将患者分为对照组(30例)和观察组(33例)。对照组采取动脉化疗栓塞治疗,观察组采取动脉化疗栓塞联合射频消融治疗。比较两组治疗后的有效止血率、复发出血率、急性肝功能衰竭率,对治疗后两组的肝功能及肿瘤指标水平及不良反应进行比较。结果 观察组的有效止血率、复发出血率等治疗各指标均优于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血清TBiL、ALT、AST指标水平均低于对照组,差异有统计学意义(P<0.05)。AFP指标水平差异无统计学意义(P> 0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论 实施动脉化疗栓塞与射频消融联合治疗可提高对肝癌自发性破裂出血患者治疗效果,可较好地改善患者肝功能及肿瘤指标水平,减少出血复发,安全性较佳,对肝癌自发性破裂出血的急症治疗具有较好的应用价值。Objective This study aims to evaluate the therapeutic effects and clinical value of emergency interventional treatment in patients with spontaneous rupture and hemorrhage due to hepatocellular carcinoma.Methods A retrospective analysis was conducted on the data of 63 patients diagnosed with spontaneous rupture and hemorrhage of hepatocellular carcinoma who were treated at Nanping Second Hospital from June 2021 to June 2024.Patients were categorized into two groups based on the surgical approach:the control group(n=30)underwent arterial chemotherapy embolization,while the observation group(n=33)received a combination of arterial chemotherapy embolization and radiofrequency ablation.The effective hemostasis rate,rate of rebleeding,and incidence of acute liver failure were compared between the two groups,along with liver function parameters,tumor markers,and adverse reactions post-treatment.Results The observation group demonstrated superior outcomes in terms of effective hemostasis rate and rebleeding rate compared to the control group,with statistically significant differences(P<0.05).However,the incidence of acute liver failure was more favorable in the control group,though this difference was not statistically significant(P>0.05).Post-treatment,the levels of serum total bilirubin,ALT,and AST in the observation group were significantly lower than those in the control group(P<0.05),while the difference in AFP levels was not statistically significant(P>0.05).Additionally,the incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion The combination of arterial chemotherapy embolization and radiofrequency ablation significantly enhances the treatment efficacy for patients with spontaneous rupture and hemorrhage due to hepatocellular carcinoma.This approach effectively improves liver function and tumor marker levels,reduces the risk of rebleeding,and exhibits a favorable safety profile,indicating its substantial clinical value in the emergency management of thi

关 键 词：肝癌 自发性破裂出血 动脉化疗栓塞 射频消融 

分 类 号：R735.7[医药卫生—肿瘤]