针灸治疗阿尔兹海默病机制研究的可视化分析  

Mechanism of Acupuncture and Moxibustion in Treatment of Alzheimer's Disease Based on CiteSpace Visualization

作　　者：袁慧 唐纯志 YUAN Hui;TANG Chun-zhi(Clinical Medical College of Acupuncture,Moxibustion,and Rehabilitation,Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510405)

机构地区：[1]广州中医药大学针灸康复临床医学院,广东广州510405

出　　处：《世界中西医结合杂志》2025年第2期229-238,共10页World Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金面上项目(82174479)。

摘　　要：目的 通过可视化图谱分析针灸治疗阿尔兹海默病(Alzheimer disease, AD)机制研究的发展现状和前沿热点。方法 检索Web of Science核心合集数据库1985年1月—2023年10月收录的相关文献,对符合条件的文献运用CiteSpace软件进行发文趋势、机构、作者、文献共被引、关键词的可视化分析。结果 共纳入171篇文献,发文量呈上升趋势;作者合作图谱中共有182位作者,形成了五个主要科研团队;机构合作图谱共有114个节点,发文量最高的机构是北京中医药大学;共有7篇文献具有重大参考意义;关键词共现分析共有231个节点被纳入,形成了10个聚类。结论 通过可视化分析可知目前针灸治疗AD机制研究正处于稳步发展阶段,“Aβ沉积、神经炎症、自噬、葡萄糖代谢、脑-肠轴、信号通路、蛋白激酶”为该领域的热点研究,后续研究可从上述方面入手。Objective To analyze the development status and emerging research hotspots of acupuncture and moxibustion treatment mechanisms for Alzheimer's disease(AD)using CiteSpace visualization.Methods Relevant literature published between January 1985 and October 2023 was retrieved from the Web of Science Core Collection database.The eligible documents were analyzed using CiteSpace software for trends in publication,institutions,authors,co-citations,and keywords.Results A total of 171 articles were included,showing an upward trend in the number of publications.The author collaboration map involved 182 authors,forming five major research teams.The institutional collaboration map contained 114 nodes,with the highest number of publications from Beijing University of Chinese Medicine.Seven articles were identified as having significant reference value.The keyword co-occurrence analysis identified 231 nodes,which formed 10 clusters.Conclusion The CiteSpace visualization shows that research on acupuncture and moxibustion treatment mechanisms for AD is steadily progressing.The key research hotspots in this field include"Aβdeposition,neuroinflammation,autophagy,glucose metabolism,gut-brain axis,signaling pathways,and protein kinases".Future studies could focus on these areas to further advance the field.

关 键 词：针灸 阿尔兹海默病 机制 可视化分析 

分 类 号：R741[医药卫生—神经病学与精神病学]