香连化浊颗粒联合脐灸及四联疗法治疗幽门螺杆菌阳性胃炎患者的疗效及对其胃肠功能、胃镜黏膜征象积分、幽门螺杆菌清除率的影响  

Efficacy of Xianglian Huazhuo Granules Combined with Umbilical Moxibustion and Quadruple Therapy on Helicobacter pylori Positive Gastritis and its Impact on Gastrointestinal Function,Gastroscopy Mucosal Sign Score,and Helicobacter pylori Clearance Rate

作　　者：孙素娇[1] 梁竹贤 范苏娟 王晓倩 王瑞锦[1] 赵璇 李金辉 SUN Su-jiao;LIANG Zhu-xian;FAN Su-juan;WANG Xiao-qian;WANG Rui-jin;ZHAO Xuan;LI Jin-hui(Hebei Provincial Traditional Chinese Medicine Hospital,Shijiazhuang Hebei 050000)

机构地区：[1]河北省中医院,河北石家庄050000

出　　处：《世界中西医结合杂志》2025年第2期365-369,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局科研计划项目(2022324)。

摘　　要：目的探究香连化浊颗粒联合脐灸治疗幽门螺杆菌(Helicobacter pylori,Hp)阳性胃炎患者的疗效及对其胃肠功能、胃镜黏膜征象积分、Hp清除率的影响。方法选取2022年12月—2024年1月期间河北省中医院收治的86例Hp阳性胃炎患者,按随机数字表法分为对照组和观察组,每组各43例。对照组采取四联疗法,观察组在对照组基础上采取香连化浊颗粒联合脐灸治疗,均治疗2周。观察比较两组患者治疗前后中医证候积分,胃动力指标[胃窦收缩频率(Antral contraction frequency,ACF)、胃窦收缩幅度(Antral contraction amplitude,ACA)、胃半排空时间],胃功能指标[胃蛋白酶原(PepsinogenⅠ、Ⅱ,PGⅠ、PGⅡ)含量,胃蛋白酶原比值(Pepsinogen ratio,PGR)],胃镜黏膜征象积分,并统计Hp清除率,复发率及治疗总有效率。结果治疗2周后两组患者中医证候积分较治疗前明显降低,差异有统计学意义(P<0.05);且观察组中医证候积分明显低于对照组,差异有统计学意义(P<0.05)。治疗2周后两组患者ACF、ACA均较治疗前明显升高,胃半排空时间均较治疗前明显缩短,差异有统计学意义(P<0.05);且观察组ACF、ACA明显高于对照组,胃半排空时间明显短于对照组,差异有统计学意义(P<0.05)。治疗2周后两组患者胃功能指标(PGⅠ、PGⅡ以及PGR)均较治疗前明显升高,差异有统计学意义(P<0.05);且观察组胃功能指标明显高于对照组,差异有统计学意义(P<0.05)。治疗2周后两组患者胃镜黏膜征象积分均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组胃镜黏膜征象各项指标积分均明显低于对照组,差异有统计学意义(P<0.05)。治疗2周后观察组Hp清除率90.70%(39/43)高于对照组69.77%(30/43),6个月内观察组Hp复发率9.30%(4/43)明显低于对照组27.91%(12/43),差异有统计学意义(P<0.05)。治疗后观察组临床总有效率93.02%(40/43)明显高于对照组69.77%(30/43),差异有统计学意义(P<0.05)Objective To explore the effect of Xianglian Huazhuo granules combined with umbilical moxibustion on Helicobacter pylori(Hp)positive gastritis and its impact on gastrointestinal function,gastroscopy mucosal sign score,and Hp clearance rate.Methods A total of 86 patients with Hp positive gastritis treated at Hebei Provincial Traditional Chinese Medicine Hospital from December 2022 to January 2024 were selected for the study.The patients were divided into a control group and an observation group using a random number table method,with 43 cases in each group.Both groups were treated for 2 weeks.The control group was given quadruple therapy while the observation group,except for the same quadruple therapy,was additionally treated with Xianglian Huazhuo granules combined with umbilical moxibustion.The following aspects were observed and compared in the patients of both groups before and after corresponding treatment:the Traditional Chinese Medicine Symptom score,gastric motility indicators[Antral Contraction Frequency(ACF),Antral Contraction Amplitude(ACA),and gastric half emptying time],gastric function indicators[pepsinogen I,I,PG I,PG I content,Pepsinogen Ratio(PGR)],gastroscopy mucosal sign scores.Besides,Hp clearance rate,recurrence rate,and total treatment efficacy were calculated.Results After 2 weeks of treatment,the TCM syndrome scores of patients in the two groups decreased significantly compared to those before treatment,and the difference was statistically significant(P<.05).The TCM syndrome score of the observation group was significantly lower than that of the control group(P<0.05).After 2 weeks of treatment,both groups of patients showed significant increases in ACF and ACA compared to the condition before treatment,with the gastric emptying time significantly shortened compared to that before treatment(P<0.05).Specifically,the ACF and ACA of the observation group were significantly higher than those of the control group,with the gastric emptying time significantly shorter than that of the control group

关 键 词：香连化浊颗粒 脐灸 幽门螺旋杆菌 胃炎 胃动力 胃镜黏膜征象 

分 类 号：R573.3[医药卫生—消化系统]