丙戊酸镁与碳酸锂治疗双相情感障碍的效果对比  

Comparative Observation of Magnesium Valproate and Iithium Carbonate in the Treatment of Bipolar Disorder

作　　者：陈海涛 CHEN Haitao(Department of Psychiatry,Nehe Renkang Mental Hospital,Qiqihar,Heilongjiang 161300,China)

机构地区：[1]齐齐哈尔市讷河仁康精神病医院精神科,黑龙江齐齐哈尔161300

出　　处：《中国医药指南》2025年第8期81-83,共3页Guide of China Medicine

摘　　要：目的 探讨丙戊酸镁与碳酸锂缓释片治疗双相情感障碍(BD)患者的临床效果。方法 选取2022年1月至2024年1月讷河仁康精神病医院精神科收治BD患者90例,根据治疗方式的不同分为观察组(47例)和对照组(43例),两组患者均常规给予奥氮平口服治疗,观察组加用碳酸锂缓释片,对照组加用丙戊酸镁缓释片,治疗周期为8周。观察两组患者临床效果、治疗前后躁狂症状量表(BRMS)评分及不良反应发生情况。结果 观察组治疗总有效率高于对照组(P <0.05)。治疗前,两组BRMS评分比较,差异无统计学意义(P> 0.05);治疗后,两组BRMS评分均低于治疗前,且观察组评分低于对照组。两组不良反应总发生情况对比,差异无统计学意义(P> 0.05)。结论 与丙戊酸镁相比,碳酸锂对BD的总有效率更高,能够改善BD患者的狂躁及抑郁状态,且具有较高安全性。Objective To investigate the clinical efficacy of magnesium valproate and lithium carbonate sustained-release tablets were added to treat patients with bipolar disorder(BD).Methods A total of 90 patients with BD from the psychiatric department of Nekhe Renkang Mental Hospital from January 2022 to January 2024 were selected.According to different treatment methods,they were divided into an observation group(47 cases)and a control group(43 cases).Both groups of patients received routine oral treatment with olanzapine,while the observation group received lithium carbonate sustained-release tablets and the control group received magnesium valproate sustained-release tablets.The treatment period was 8 weeks.The clinical effective,manic symptom scale(BRMS),and adverse reactions before and after treatment in two groups of patients were observed.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).Before treatment,there was no statistically significant difference in BRMS scores between the two groups(P>0.05).After treatment,the BRMS scores of both groups were lower than before treatment,and the observation group had lower scores than the control group.There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusions Compared with magnesium valproate,lithium carbonate has a higher total effective rate for BD,can significantly improve patients’manic and depressive states,and has high safety.

关 键 词：双相情感障碍 丙戊酸镁 碳酸锂 疗效 

分 类 号：R749.4[医药卫生—神经病学与精神病学]