原发性前列腺鳞癌1例:个案报道暨文献复习  

Primary Prostate Squamous Cell Carcinoma:A Case Report and Literature Review

作　　者：韩兴月 李曾[2] 周术奎 吴毅[2] 肖英明[2] 刘金鹏 杨盛柯 廖洪[2] Han Xingyue;Li Zeng;Zhou Shukui;Wu Yi;Xiao Yingming;Liu Jinpeng;Yang Shengke;Liao Hong(School of Clinical Medicine,Chengdu Medical College,Chengdu 610500,Sichuan,China;Department of Urology,Sichuan Clinical Research Center for Cancer,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,University of Electronic Science and Technology of China,Chengdu 610041,Sichuan,China)

机构地区：[1]成都医学院临床医学院,成都610500 [2]四川省肿瘤医院·研究所,四川省肿瘤临床医学研究中心,四川省癌症防治中心,电子科技大学附属肿瘤医院,成都610041

出　　处：《肿瘤预防与治疗》2025年第1期42-49,共8页Journal of Cancer Control And Treatment

基　　金：四川省科技厅重点研发项目(编号:2020YFS0421);四川省卫生健康委员会医学科技项目(编号:2023LCYJ004)。

摘　　要：目的:原发性前列腺鳞状细胞癌(prostate squamous cell carcinoma, PSCC)临床罕见,治疗效果有限,预后不佳,平均生存时间约为14个月。本研究旨在对国内PSCC患者的临床病理特征和诊治特点进行总结分析。方法:从中国知网、万方等数据库收集从2001年1月至2023年12月期间报道诊断为原发性PSCC的患者并结合我们收治的1例患者进行回顾性队列研究,分析其临床表现、病理特点等特征和治疗预后等,通过Kaplan-Meier法进行生存分析。结果:29例PSCC患者中,其中16例(55.2%)居住在沿海地区;中位发病年龄为66岁(47~87),以排尿困难为主要症状的有25例(86.2%);PSA升高1例(3.4%),低分化10例(34.5%),中高分化17例(58.6%);14例(48.3%)在诊断时已转移,Ⅰ~Ⅱ期13例(44.8%),Ⅲ~Ⅳ期16例(55.2%);5例(17.2%)接受了根治性前列腺切除手术,8例(27.6%)接受了化疗,14例(48.3%)接受了放疗;未提及预后情况4例(13.8%),16例(55.2%)病情稳定、存活,最终死亡9例(31.0%)。生存分析显示放疗与生存期显著相关(P=0.020)。结论:本研究结合本科室诊治的1例PSCC,较系统地总结了我国现有文献报道的原发性PSCC的临床病理特征和诊治特点,发现PSCC在诊断时通常是高级别和转移性的,预后较差,放疗有助于减少肿瘤复发和改善PSCC患者的预后。Objective:Primary prostate squamous cell carcinoma(PSCC)is a rare disease with a limited response to treatment and a poor prognosis,with a median survival time of approximately 14 months.This study aims to gather and ana-lyze the clinicopathological,diagnostic,and treatment data of PSCC patients in China.Methods:Patients diagnosed as primary PSCC published from January 2001 to December 2023 were gathered from China National Knowledge Infrastructure Database and Wanfang Database.These patients were then included in a retrospective cohort study,along with one patient treated by our team,to analyze their clinical manifestations,pathology and prognosis.Survival analysis was conducted using the Kaplan-Meier method.Results:Among the 29 patients diagnosed as PSCC,16(55.1%)resided in coastal areas.The median age of onset was 66 years(ranging from 47 to 87).The main symptom for 25 patients(86.2%)was difficulty in urination.Only 1 patient(3.5%)had an elevated prostate specific antigen level.Poor differentiation was observed in 10 patients(34.4%),while moderate and well differentiation was seen in 17 patients(58.6%).Metastasis was present at the time of diagnosis in 14 patients(48.2%),with 13(44.8%)in stage I-II and 16(55.1%)in stage I1-IV.Radical prostatectomy was performed on 55 patients,8 received chemotherapy,and 14 underwent radiotherapy.Prognosis was not reported for four patients,while 16 had stable conditions and survived.9 patients passed away.Survival analysis indicated a significant correlation between radiotherapy and survival(P=0.020).Conclusion:Combined with a case of PSCC diagnosed and treated in our department,this study offers a comprehensive overview of the clinicopathological features,diagnostic methods,and treatment approaches for reported primary PSCC in China,indicating that PSCC is usually advanced and metastatic when diagnosed,and the prognosis is poor.The use of radiotherapy has shown promise in reducing tumor recurrence and enhancing the overall prognosis for individuals with PSCC.

关 键 词：前列腺恶性肿瘤 放疗 诊断 

分 类 号：R737.2[医药卫生—肿瘤]