牙龈卟啉单胞菌的LuxS/AI-2型群体感应系统及其抑制剂的研究进展  

Progress of the LuxS/AI-2 quorum sensing system and its inhibitors in Porphyromonas gingivalis

作　　者：于刘平 曹彦南 胡美纯 张天楷 丁壮 高宇峰 张延晓 朱房勇 Yu Liuping;Cao Yannan;Hu Meichun;Zhang Tiankai;Ding Zhuang;Gao Yufeng;Zhang Yanxiao;Zhu Fangyong(Wuxi Medical College of Jiangnan University,Wuxi 214122,China;Department of Stomatology,Affiliated Hospital of Jiangnan University,Wuxi 214122,China;Department of Stomatology,Medical College of Nantong University,Nantong 226001,China;Wuxi People′s Hospital,Wuxi 214023,China;Department of Orthodontics,Wuxi Stomatology Hospital,Wuxi 214000,China)

机构地区：[1]江南大学无锡医学院,无锡214122 [2]江南大学附属医院口腔科,无锡214122 [3]南通大学医学院口腔医学系,南通226001 [4]无锡市人民医院,无锡214023 [5]无锡口腔医院正畸科,无锡214000

出　　处：《中华微生物学和免疫学杂志》2025年第2期168-174,共7页Chinese Journal of Microbiology and Immunology

基　　金：无锡市双百拔尖人才项目(HB2023054);无锡市卫计委面上项目(M202240)。

摘　　要：牙龈卟啉单胞菌是导致多种口腔疾病和全身疾病的重要致病菌。LuxS/AI-2型群体感应系统在调控牙龈卟啉单胞菌生物膜形成、毒力因子及耐药性等众多生理过程中起关键作用。群体感应抑制剂(quorum sensing inhibitors)是一种新型的潜在抗生素替代品,在抑制生物膜形成、细菌毒力和不诱导抗生素耐药性下破坏群体感应过程,是控制细菌感染的新方法。本综述从LuxS/AI-2群体感应系统调控牙龈卟啉单胞菌生物膜形成、毒力、耐药性及其群体感应抑制剂的研究进展做一总结,为进一步研究针对牙龈卟啉单胞菌LuxS/AI-2型群体感应系统抑制靶点提供理论依据。Porphyromonas gingivalis is an important pathogenic bacterium causing a variety of oral and systemic diseases.The LuxS/AI-2 quorum sensing system plays a key role in regulating numerous physiological processes such as biofilm formation,virulence factors and drug resistance in Porphyromonas gingivalis.Quorum sensing inhibitors are a new potential antibiotic substitute,a new method to control bacterial infection under the inhibition of biofilm formation,bacterial virulence and no induction of antibiotic resistance.This review is a summary of the research progress of the LuxS/AI-2 quorum sensing system in regulating biofilm formation,virulence,resistance and quorum sensing inhibitors in Porphyromonas gingivalis,and provides a theoretical basis for further research on the inhibitory targets of the LuxS/AI-2 quorum sensing system in Porphyromonas gingivalis.

关 键 词：牙龈卟啉单胞菌 LuxS/AI-2型群体感应系统 群体感应抑制剂 

分 类 号：R78[医药卫生—口腔医学]