NLRC3在免疫应答及免疫相关疾病方面的研究进展  

Progress in roles of NLRC3 in immune response and immune-related diseases

作　　者：孟娜 许文娟 Meng Na;Xu Wenjuan(Department of Respiratory and Critical Care Medicine,the Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院呼吸与危重症医学科,青岛266000

出　　处：《中华微生物学和免疫学杂志》2025年第2期175-180,共6页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金青年基金(82200022)。

摘　　要：NOD样受体家族胱天蛋白酶激活和募集结构域蛋白3(NOD-like receptor family with a caspase activation and recruitment domain containing 3,NLRC3)作为NOD样受体中的负向调控分子,在免疫应答的抗原识别提呈阶段、淋巴细胞增殖活化阶段以及免疫效应阶段通过p38信号分子、NF-κB-活化T细胞核因子5复合物(NF-κB-nuclear factor of activated T cells 5 complex,NF-κB-NFAT5)和丝裂原活化蛋白激酶/细胞外调节蛋白激酶(mitogen-activated protein kinase/extracellular regulated protein kinase,MEK/ERK)信号通路等多种机制发挥抑制作用,在诸多免疫相关疾病,包括感染性疾病、自身免疫性疾病和肿瘤等疾病进程中具有重要调控作用。本文综述了NLRC3分子在不同免疫应答阶段和免疫相关疾病中的作用及机制。NOD-like receptor family with a caspase activation and recruitment domain containing 3(NLRC3),as a negative regulator in NOD-like receptors,plays a suppressive role in the antigen recognition and presentation phase,lymphocyte proliferation and activation phase,and antigen elimination phase mainly through interacting with p38 signaling molecule,NF-κB-nuclear factor of activated T cells 5 complex(NF-κB-NFAT5)signaling pathway,and mitogen-activated protein kinase/extracellular regulated protein kinase(MEK-ERK)signaling pathway.Moreover,NLRC3 plays a crucial role in many immune-related diseases,such as infectious disease,autoimmune diseases,and tumor.In this review,the various functions and related mechanisms of NLRC3 in different immune response phases and immune-related diseases are summarized.

关 键 词：NOD样受体 NLRC3 免疫应答 免疫相关疾病 

分 类 号：R73[医药卫生—肿瘤]