Bridge over troubled cells: bone marrow stromal cells transfer mitochondria to boost T cells  

作　　者：Lars Fabian Prinz Roland Tillmann Ullrich Markus Martin Chmielewski 

机构地区：[1]Department I of Internal Medicine,University Hospital Cologne and Faculty of Medicine,University of Cologne,50937,Cologne,Germany [2]Translational Research for Infectious Diseases and Oncology(TRIO),50931,Cologne,Germany [3]Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf,University Hospital Cologne,50937,Cologne,Germany

出　　处：《Signal Transduction and Targeted Therapy》2025年第1期7-9,共3页信号转导与靶向治疗(英文)

基　　金：supported by Deutsche Forschungsgemeinschaft grant 455784452 as part of SFB 1530 project B05 to L.F.P.,R.T.U and M.M.C.;DFG grant 435414693 to M.M.C.M.M.C is further supported by Köln Fortune project 87/2023 and 124/2023.

摘　　要：In an article published in Cell in September 2024,Baldwin and colleagues present a bone marrow stromal cell(BMSC)based mitochondrial transfer platform to combat mitochondrial dysfunction or scarcity in human T cells ex-vivo.1 This thorough and methodically diverse investigation results in a promising technology at a time when adoptive T cell therapies seem to run against a wall of T cell exhaustion and dysfunction in treatments targeting solid tumors.

关 键 词：MARROW bone TRANSFER 

分 类 号：R73[医药卫生—肿瘤]