TCP1在初诊急性髓系白血病患者中的表达及其临床意义  

The Expression and Clinical Significance of TCP1 in Newly Diagnosed Acute Myeloid Leukemia Patients

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作  者:李佳佳 伍燕平 刘林 张孟孟 王蒙 张平平 张凤 LI Jia-Jia;WU Yan-Ping;LIU Lin;ZHANG Meng-Meng;WANG Meng;ZHANG Ping-Ping;ZHANG Feng(Department of Hematology,The First Affiliated Hospital of Bengbu Medical University,Bengbu 233003,Anhui Province,China)

机构地区:[1]蚌埠医科大学第一附属医院血液科,安徽蚌埠233003

出  处:《中国实验血液学杂志》2025年第2期339-343,共5页Journal of Experimental Hematology

基  金:安徽省自然科学基金青年项目(2108085QH324);安徽省卫生健康科研重点项目(AHWJ2023A10059)。

摘  要:目的:探讨初诊急性髓系白血病(AML)患者骨髓中T复合多肽1(TCP1)的表达水平及其与患者临床特征和预后的相关性。方法:收集80例初诊AML患者和30例缺铁性贫血患者骨髓标本,采用实时荧光定量PCR法检测TCP1的表达水平。收集AML患者的临床资料,分析TCP1表达水平与临床特征及预后的关系。使用Kaplan-Meier曲线分析TCP1对AML患者总体生存时间(OS)的影响,Cox回归分析影响AML患者预后的因素。结果:与缺铁性贫血患者相比,TCP1在AML患者中表达明显升高(P<0.01)。与TCP1低表达组相比,TCP1高表达组年龄≥60岁患者和治疗后未缓解患者所占比例较高,患者多伴有TET2基因突变,且预后不良明显增多,而中位OS缩短(均P<0.05)。多因素Cox分析结果显示,年龄、染色体核型异常、疗效及TCP1表达量是影响AML患者预后的独立危险因素(均P<0.05)。结论:TCP1在AML患者中明显上调,其表达与部分临床特征及不良预后相关,可作为判断AML患者预后的生物标志物和潜在的治疗靶点。Objective:To detect the expression level of T-complex polypeptide 1(TCP1)in the bone marrow of newly diagnosed acute myeloid leukemia(AML)patients,and explore its correlation with clinical characteristics and prognosis.Methods:The bone marrow samples from 80 newly diagnosed AML patients and 30 iron deficiency anemia(IDA)patients were collected,and real time fluorescence quantitative PCR was used to detect the expression level of TCP1.The clinical data of AML patients were collected,and the correlation of TCP1 expression with clinical characteristics and prognosis of patients were analyzed.The impact of TCP1 on overall survival(OS)of AML patients was identified by using Kaplan-Meier curve analysis.Cox regression analysis was used to identify the factors affecting prognosis of AML patients.Results:Compared with IDA patients,the expression of TCP1 was significantly increased in AML patients(P<0.01).The high expression group of TCP1 showed a higher proportion of patients with≥60 years and non-remission after treatment,more accompanied by TET2 mutation and poor prognosis but shorter OS compared to the low expression group(all P<0.05).The results of multivariate Cox regression analysis showed that age,chromosomal abnormalities,therapeutic efficacy and TCP1 expression were independent risk factors affecting prognosis of AML patients(all P<0.05).Conclusion:TCP1 is significantly upregulated in AML patients,and its expression is associated with partial clinical features and poor prognosis.It can serve as a prognostic indicator and potential therapeutic target for AML patients.

关 键 词:急性髓系白血病 T复合多肽1 预后 

分 类 号:R733.71[医药卫生—肿瘤]

 

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