回顾性分析福建宁德市23例成人T细胞白血病/淋巴瘤患者临床特征与预后情况及抗病毒治疗疗效观察  

Clinical Features and Prognosis of 23 Cases of Adult T-Cell Leuke-mia/Lymphoma in Ningde City,Fujian Province and Efficacy of Antiviral Therapy---a Retrospectively Analysis

作　　者：王长贵 陈仁利 赖晓兰 WANG Chang-Gui;CHEN Ren-Li;LAI Xiao-Lan(Department of Hematology,Ningde Affiliated Hospital of Ningde Normal University,Ningde 352100,Fujian Province,China)

机构地区：[1]宁德师范学院附属宁德市医院血液科,福建宁德352100

出　　处：《中国实验血液学杂志》2025年第2期359-364,共6页Journal of Experimental Hematology

摘　　要：目的:分析福建省宁德市成人T细胞白血病/淋巴瘤(ATLL)患者的临床特征及预后情况。方法:回顾性收集2014年5月至2023年12月期间就诊于宁德师范学院附属宁德市医院血液科出院诊断为成人T细胞白血病/淋巴瘤的23例病例,总结其临床特征,分析预后情况。对比单纯化疗和化疗联合抗病毒治疗患者的生存期。结果:23例患者均来自福建沿海ATLL流行区(宁德市),男性12例,女性11例,中位发病年龄59(31-84)岁。临床类型均为急性型(18例)或淋巴瘤型(5例),未见冒烟型、慢性型。最常见的临床表现依次为白细胞增高20例,淋巴结肿大19例、皮肤损害13例、高钙血症13例,90%以上的病例出现乳酸脱氢酶(LDH)升高,11例患者β2-微球蛋白升高。23例患者中12例接受化疗(部分联合抗病毒治疗),仅1例接受异基因造血干细胞移植。总体中位生存期为2.3(0.2-13)个月。化疗联合抗病毒治疗组中位生存期为3(2-11)个月,单纯化疗组中位生存期为2(0.2-13)个月。结论:福建宁德市成人ATLL临床特征较典型,预后不良,抗病毒治疗可能有助于改善预后。Objective:To analyze the clinical characteristics and prognosis of patients with adult T-cell leukemia/lymphoma(ATLL)in Ningde City,Fujian Province.Methods:We retrospectively collected 23 cases diagnosed with adult T-cell leukemia/lymphoma in the Hematology Department of Ningde Hospital Affiliated to Ningde Normal University from 2014 to 2023,the clinical characteristics of patients were summarized and the prognosis was analyzed.The survival of patients treated with chemotherapy alone and chemotherapy combined with antiviral therapy was compared.Results:All 23 patients were from the coastal endemic area of Fujian(Ningde City),12 males and 11 females.The median age of onset was 59(range:31-84)years old.The clinical types were acute(18 cases)or lymphomatous(5 cases),and no smoldering or chronic type was seen.The most common clinical manifestations were,in order of prevalence,20 cases of leukocytosis,19 cases of lymph node enlargement,13 cases of skin lesions,13 cases of hypercalcemia.There was an elevation of lactate dehydrogenase(LDH)levels in more than 90%of cases,andβ2-microglobulin levels were elevated in 11 cases.Twelve of the 23 patients were treated with chemotherapy(partly in combination with antiviral therapy),one underwent allogeneic hematopoietic stem cell transplantation.The median overall survival of all patients was 2.3(0.2-13)months.Median survival was 3(2-11)months in the chemotherapy combined with antiviral therapy group,while that of the chemotherapy alone group was 2(0.2-13)months.Conclusion:The clinical manifestations of adult T-cell leukemia/lymphoma in Ningde city,Fujian province are characteristic and the prognosis is unfavorable.Antiviral therapy may contribute to an improvement in the prognosis.

关 键 词：成人T细胞白血病/淋巴瘤 临床表现 预后 

分 类 号：R733.7[医药卫生—肿瘤]