铁在淋巴细胞和浆细胞疾病中的作用机制  

The Mechanism of Iron in Lymphocyte and Plasma Cell Diseases--Review

作　　者：罗书林 杨斐斐 徐燕丽[1] LUO Shu-Lin;YANG Fei-Fei;XU Yan-Li(Department of Hematology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210000,Jiangsu Province,China)

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)血液内科,江苏南京210000

出　　处：《中国实验血液学杂志》2025年第2期601-605,共5页Journal of Experimental Hematology

基　　金：国家自然科学基金项目(82000160);南京市卫生科技发展项目(YKK21138)。

摘　　要：铁作为一种重要的微量元素,参与机体的多种生理过程。研究发现,肿瘤的发生发展与铁代谢异常密切相关,且作用方式呈现明显异质性。肿瘤细胞需要更多的铁来促进自身存活和增殖,但过量的铁也会对肿瘤细胞产生不利的影响,如铁死亡等。铁死亡是一种特殊的调节性细胞死亡机制,不同于其他的细胞调节死亡途径,其主要通过铁依赖的过氧化脂质和活性氧(ROS)过度积累,从而诱导细胞死亡。在血液系统中,淋巴瘤及多发性骨髓瘤(MM)的肿瘤细胞都对铁死亡较敏感,且通过多种机制影响疾病进展。本文就淋巴瘤的部分亚型及MM中的铁死亡机制进行阐述,揭示血液肿瘤细胞铁死亡与血液肿瘤发生发展的相关性,旨在为治疗这些血液系统疾病提供新的思路。As an important trace element,iron is involved in a variety of physiological processes.In recent years,studies have found that the occurrence and development of tumors are closely related to abnormal iron metabolism,and the mode of action is obviously heterogeneous.Tumor cells need more iron to promote their survival and proliferation,but iron overload can also have adverse effects on tumor cells,such as ferroptosis.Ferroptosis is a special regulatory mechanism of cell death,which is different from other regulated cell death pathways.It mainly induces cell death through excessive accumulation of iron-dependent lipid peroxide and reactive oxygen species(ROS).Recent studies have found that in the blood system,tumor cells of lymphoma and multiple myeloma(MM)are more sensitive to ferroptosis and affect disease progression through a variety of mechanisms.In this review,the mechanisms of ferroptosis in some subtypes of lymphoma and MM are described in detail,and the correlation between ferroptosis of hematological tumor cells and the occurrence and development of hematological tumors is revealed,aiming to provide new ideas for the treatment of these hematological diseases.

关 键 词：淋巴瘤 多发性骨髓瘤 铁代谢 铁死亡 

分 类 号：R733.1[医药卫生—肿瘤] R733.3[医药卫生—临床医学]