T细胞耗竭在血液系统肿瘤中的最新研究进展  

The Latest Research Progress of T Cell Exhaustion in Hematologi-cal Malignancy---Review

作　　者：刘夏鑫 徐子真 李军民[1] LIU Xia-Xin;XU Zi-Zhen;LI Jun-Min(Shanghai Institute of Hematology,Department of Hematology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine;College of Health Science and Technology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院血液科,上海血液学研究所 [2]上海交通大学医学院附属瑞金医院,上海交通大学医学院医学技术学院,上海200025

出　　处：《中国实验血液学杂志》2025年第2期606-611,共6页Journal of Experimental Hematology

摘　　要：T细胞耗竭在恶性肿瘤中起免疫抑制作用。持续的肿瘤抗原刺激、肿瘤微环境中抑制性免疫细胞和细胞因子的存在、T细胞表面抑制性受体表达的上调、T细胞相关转录因子的变化以及肿瘤微环境中的代谢产物都可能导致T细胞耗竭。逆转肿瘤患者体内的耗竭性T细胞是颇具前景的肿瘤免疫治疗策略。本文将对血液系统肿瘤中T细胞耗竭状态、发生机制、逆转方法以及临床应用的最新研究进展作一综述。T cell exhaustion plays an immunosuppressive role in malignant tumors.Continuous tumor antigen stimulation,the presence of suppressive immune cells and cytokines in the tumor microenvironment,the up regulation of inhibitory receptor expression on the surface of T cells,changes in T cell related transcription factors,and metabolites in the tumor microenvironment may lead to T cell exhaustion.Reversing the exhaustion of T cells in tumor patients is a promising strategy for tumor immunotherapy.This article will review the latest research progress on T cell exhaustion status,pathogenesis,reversal methods,and clinical applications in hematological tumors.

关 键 词：T细胞耗竭 血液系统肿瘤 免疫治疗 

分 类 号：R730.51[医药卫生—肿瘤]