Microbial production of chondroitin sulfate and its derivatives  

作　　者：Jine Li Jihui Zhang Huarong Tan 

机构地区：[1]State Key Laboratory of Microbial Resources,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China [2]College of Life Sciences,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Science China(Life Sciences)》2025年第3期871-873,共3页中国科学(生命科学英文版)

基　　金：supported by the National Key Research and Development Program of China(2021YFC2103200);the National Natural Science Foundation of China(32270055).

摘　　要：With a global increase of aging populations,chondroitin sulfate(CS)is heavily demanded to treat the high incidence of osteoarthritis.CS is a type of polysaccharide derived from animal cartilage with outstanding anti-inflammatory properties.However,the limited supply of raw materials makes it difficult to meet the growing requirement.With the launch of the first animal-free CS,Mythocondro^(TM),which is biosynthesized through fermentation of an engineered E.coli strain combined with chemical sulfation in vitro,the interest in microbial biosynthesis of CS has greatly increased.This article highlights the recent advances in microbial biosynthesis of CS and its derivatives,analyzes the current challenges and provides possible proposals for future development.

关 键 词：PROPERTIES DERIVATIVES SULFATE 

分 类 号：TQ920.6[轻工技术与工程—发酵工程] TQ460.1