癫痫血清MDA、SOD、CAT水平与发作程度及认知功能的相关性分析  

Correlation Analysis of Serum MDA,SOD and CAT Levels with Seizure Degree and Cognitive Function in Epileptic Patients

作　　者：任腾飞 班曼曼 李翠 郭艳平[3] REN Teng-fei;BAN Man-man;LI Cui;GUO Yan-ping(Department of Neurology,Zhengzhou Yihe Hospital,Zhengzhou 450007,Henan Province,China;Department of Neurology,Zhengzhou Western Hospital of Traditional Chinese Medicine,Zhengzhou 450001,Henan Province,China;Department of Neurology,Anyang People's Hospital,Anyang 455000,Henan Province,China)

机构地区：[1]郑州颐和医院神经内科,河南郑州450007 [2]郑州西区中医院神经内科,河南郑州450001 [3]安阳市人民医院神经内科,河南安阳455000

出　　处：《罕少疾病杂志》2025年第3期28-30,共3页Journal of Rare and Uncommon Diseases

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20191269)。

摘　　要：目的 探讨癫痫患者超氧化物歧化酶(SOD)、丙二醛(MDA)、过氧化氢酶(CAT)水平与其发作程度及认知功能的相关性。方法 纳入2020年10月至2022年10月本院癫痫患者96例,比较不同认知功能障碍损害程度及不同发作类型的癫痫患者血清MDA、SOD、CAT水平,探讨血清MDA、SOD、CAT水平与发作程度、认知功能的相关性。结果 96例癫痫患者中轻度认知功能障碍33例,.中度认知功能障碍43例,重度认知功能障碍20例。血清MDA水平比较:轻度组>中度组>重度组,血清SOD、CAT水平比较:轻度组<中度组.<重度组(P<005)。96例癫痫患者中全身强直阵挛发作42例,部分性发作54例;全身强直阵挛发作者与部.分性发作者血清MDA、SOD、CAT水平相当(P>005)。Pearson相关分析结果显示,癫痫患者血清MDA水平与NHS3评分正相关,与MoCA评分负相关(P<005),血清SOD、CAT水平与MoCA评分正相关(P<005)。结论 癫痫患者血清MDA水平升高,血清SOD和CAT水平降低,其中血清MDA水平与癫痫发作严重程度和认知功能密切相关,而血清SOD和CAT水平仅与认知功能相关。Objective To explore the correlation between the levels of superoxide dismutase(SOD),malondialdehyde(MDA),catalase(CAT)and the severity of seizures and cognitive function in epilepsy patients.Methods A total of 96 epilepsy patients in our hospital from October 2020 to October 2022 were included to compare the levels of serum MDA,SOD,and CAT in epilepsy patients with different degrees of cognitive impairment and seizure types.The correlation between serum MDA,SOD,and CAT levels and seizure severity and cognitive function was explored.Results Among the 96 epilepsy patients,33 had mild cognitive impairment,43 had moderate cognitive impairment,and 20 had severe cognitive impairment.Comparison of serum MDA levels:Mild group>Moderate group>Severe group.Comparison of serum SOD and CAT levels:Mild group<Moderate group<Severe group(P<0.05).Among 96 epilepsy patients,there were 42 cases of generalized tonic clonic seizures and 54 cases of partial seizures;The levels of serum MDA,SOD,and CAT in patients with generalized tonic clonic seizures were comparable to those in patients with partial seizures(P>0.05).Pearson correlation analysis showed that serum MDA levels in epilepsy patients were positively correlated with NHS3 scores and negatively correlated with MoCA scores(P<0.05),while serum SOD and CAT levels were positively correlated with MoCA scores(P<0.05).Conclusion The level of serum MDA in epileptic patients increased,while the level of serum SOD and CAT decreased.The level of serum MDA was closely related to the severity of epileptic seizure and cognitive function,while the level of serum SOD and CAT was only related to cognitive function.

关 键 词：癫痫 丙二醛 超氧化物歧化酶 过氧化氢酶 发作程度 认知功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学]