超声弹性成像联合血清VEGF、IL-17水平对甲状腺癌分化程度的鉴别效能  

Efficacy of Ultrasound Elastography Combined with Serum VEGF and IL-17 Levels in the Differential Diagnosis of Thyroid Cancer Differentiation

作　　者：林德威 张周龙[1] LIN De-wei;ZHANG Zhou-long(Department of Ultrasound,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan Province,China)

机构地区：[1]河南科技大学第一附属医院超声科,河南洛阳471000

出　　处：《罕少疾病杂志》2025年第3期48-50,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的 分析超声弹性成像联合血清血管内皮生长因子(VEGF)、白细胞介素-17(IL-17)水平对甲状腺癌分化程度的鉴别效能。方法 回顾性研究本院收治的268例甲状腺癌患者的临床资料,参照临床判断结果将其分为中/高分化组(187例)、低分化组(81例)。比较两组患者超声弹性成像相关参数(弹性比值、蓝色面积比值)以及血清VEGF、IL-17水平;绘制受试者工作特征(ROC)曲线分析超声弹性成像、血清VEGF、IL-17单独及联合对甲状腺癌分化程度的鉴别价值。结果 中/高分化组的弹性比值、蓝色面积比值、血清VEGF和IL-17水平均低于低分化组(P<0.05)。弹性比值、蓝色面积比值联合鉴别甲状腺癌分化程度的曲线下面积(AUC)、灵敏度、特异度分别为0.901、85.19%、87.70%,其中联合灵敏度高于单独单独鉴别,联合AUC高于单独鉴别(P<0.05),特异度与单独鉴别相近;超声弹性成像参数联合血清VEGF、IL-17鉴别甲状腺癌分化程度的的AUC、灵敏度、特异度分别为0.963、96.30%、84.49%,其中联合灵敏度高于单独单独鉴别,联合AUC高于单独鉴别(P<0.05),特异度与单独鉴别相近。结论 超声弹性成像参数与血清VEGF、IL-17均可有效鉴别甲状腺癌分化程度,但其联合鉴别价值更高。Objective To analyze the differential efficacy of ultrasound elastography combined with serum vascular endothelial growth factor(VEGF)and interleukin-17(IL-17)levels in the differentiation of thyroid cancer.Methods The clinical data of 268 patients with thyroid cancer admitted to our hospital were retrospectively analyzed.According to the results of clinical judgment,they were divided into medium/high differentiation group(187 cases)and low differentiation group(81 cases).The ultrasonic elastography related parameters(elastic ratio,blue area ratio)and serum VEGF and IL-17 levels were compared between the two groups.The receiver operating characteristic(ROC)curve was drawn to analyze the differential value of ultrasound elastography,serum VEGF and IL-17 in alone and combination to the differentiation degree of thyroid cancer.Results The elastic ratio,blue area ratio,and serum VEGF and IL-17 levels in the medium/high differentiation group were lower than those in the low differentiation group(P<0.05).The area under the curve(AUC),sensitivity and specificity of the combination of elastic ratio and blue area ratio in differentiating the degree of differentiation of thyroid cancer were 0.901,85.19%and 87.70%respectively,and the combined sensitivity was higher than that of single identification,the combined AUC was higher than that of single identification(P<0.05),and the specificity was similar to that of single identification.The AUC,sensitivity and specificity of ultrasound elastography parameters combined with serum VEGF and IL-17 in differentiating the degree of differentiation of thyroid cancer were 0.963,96.30%and 84.49%respectively,and the combined sensitivity was higher than that of single identification,the combined AUC was higher than that of single identification(P<0.05),and the specificity was similar to that of single identification.Conclusion Ultrasound elastography parameters and serum VEGF and IL-17 can effectively identify the degree of differentiation of thyroid cancer,but their combined identificati

关 键 词：甲状腺癌 超声弹性成像 血管内皮生长因子 白细胞介素-17 分化程度 鉴别效能 

分 类 号：R736.1[医药卫生—肿瘤]