基于临床病理和MRI特征联合模型对BRCA突变型卵巢癌的诊断价值  

Diagnostic value of combined model based on clinicopathological and MRI features in BRCA-mutated ovarian cancer

作　　者：张浩 陈晓红 钟鑫威 陈漪 岳博文 陈寿让 侯文忠 杨志企 陈小凤 ZHANG Hao;CHEN Xiaohong;ZHONG Xinwei;CHEN Yi;YUE Bowen;CHEN Shourang;HOU Wenzhong;YANG Zhiqi;CHEN Xiaofeng(Department of Radiology,Meizhou Clinical Medical College of Shantou University Medical College,Meizhou People’s Hospital,Meizhou,Guangdong Province 514031,China)

机构地区：[1]汕头大学医学院梅州临床学院梅州市人民医院放射科,广东梅州514031

出　　处：《实用放射学杂志》2025年第2期246-250,共5页Journal of Practical Radiology

基　　金：梅州市社会发展科技计划项目(2024C0301077);梅州市人民医院培育项目(PY-C2022011)。

摘　　要：目的探讨基于临床病理和MRI特征的联合模型对BRCA突变型卵巢癌的诊断价值。方法回顾性分析经病理及BRCA基因检测的132例卵巢癌患者资料,其中BRCA突变组52例,BRCA野生组80例。比较BRCA突变组和BRCA野生组间MRI特征和临床病理特征的差异。采用二元logistic回归构建联合预测模型并分析其诊断效能。结果BRCA突变组和BRCA野生组间细胞角蛋白7(CK7)、雌激素受体(ER)、Ki-67、淋巴脉管浸润(LVI)的差异均有统计学意义(P<0.05)。单因素分析显示CK7、ER、Ki-67、LVI和肿瘤囊性部分表观扩散系数(ADC)值是BRCA突变型卵巢癌的危险因素。基于联合CK7、ER、Ki-67、LVI和肿瘤囊性部分ADC值构建的联合模型诊断BRCA突变型卵巢癌的曲线下面积(AUC)为0.765。结论CK7、ER、Ki-67、LVI和肿瘤囊性部分ADC值是BRCA突变型卵巢癌的危险因素,基于上述特征建立的联合模型对BRCA突变型卵巢癌具有较好的诊断效能。Objective e To explore the diagnostic value of a combined model based on clinicopathological and MRI features in BRCA-mutated ovarian cancer.Methods The data of 132 patients with ovarian cancer who underwent pathology and BRCA gene tes-ting were analyzed retrospectively,including 52 cases of BRCA mutation group and 80 cases of BRCA wild group.The differences of MRI features and clinicopathological features between BRCA mutation group and BRCA wild group were compared.Binary logistic regression was used to construct a joint prediction model and analyze its diagnostic efficiency.Results There were significant differ-ences in cytokeratin 7(CK7),estrogen receptor(ER),Ki-67 and lymphovascular invasion(LVI)between the BRAC mutation group and the BRAC wild group(P<0.05).Univariate analysis showed that CK7,ER,Ki-67,LVI and the apparent diffusion coefficient(ADC)value of the cystic part of tumor were risk factors for BRCA-mutated ovarian cancer.The combined model based on CK7,ER,Ki-67,LVI,and the ADC value of the cystic part of tumor for the diagnosis of BRCA-mutated ovarian cancer had an area under the curve(AUC)of 0.765.Conclusion CK7,ER,Ki-67,LVI and the ADC value of the cystic part of tumor are risk factors for BRCA-mutated ovarian cancer.The combined model based on the above characteristics demonstrates good diagnostic efficacy for BRCA-mutated ovarian cancer.

关 键 词：卵巢癌:乳腺癌易感基因 磁共振成像 临床病理特征 诊断效能 

分 类 号：R737.31[医药卫生—肿瘤] R445.2[医药卫生—临床医学] R446.8