A tactfully designed photothermal agent collaborating with ascorbic acid for boosting maxillofacial wound healing  

作　　者：Yuxin Qian Yiting Gao Dong Wang Shixuan Zhang Qiuxia Luo Guogang Shan Mengmeng Lu Dingyuan Yan Ben Zhong Tang Ming Zhang 

机构地区：[1]Department of Oral Implantology,The Affiliated Stomatological Hospital of Nanjing Medical University.State Key Laboratory Cultivation Base of Research,Prevention and Treatment for Oral Diseases.Jiangsu Province Engineering Research Center of Stomatological Translational Medicine,Nanjing Medical University,Nanjing 210029,China [2]Institute of Functional Material Chemistry and National&Local United Engineering Lab for Power Battery,Faculty of Chemistry,Northeast Normal University,Changchun 130024,China [3]Center for AIE Research,Guangdong Provincial Key Laboratory of New Energy Materials Service Safety,College of Materials Science and Engineering,Shenzhen University,Shenzhen 518060,China [4]School of Science and Engineering,Shenzhen Institute of Aggregate Science and Technology,The Chinese University of Hong Kong,Shenzhen(CUHK-Shenzhen),Shenzhen 518172,China

出　　处：《National Science Review》2025年第2期238-252,共15页国家科学评论(英文版)

基　　金：supported by the Medical-Engineering Inter-disciplinary Research Foundation of Shenzhen University(2023YG021);the Natural Science Foundation of Jiangsu Province(BK20240513 and BK20241863).

摘　　要：Maxi l lofacial injuries that may cause severe functional and aesthetic damage require effective and immediate management due to continuous exposure to diverse microbial populations.Moreover,drug resistance,biofilm formation,and oxidative stress significantly impede timely bacterial removal and immune function,making the exploration of advanced materials for maxi l lofacial wound healing an appealing yet highly challenging task.Herein,a near-infrared photothermal sterilization agent was designed,encapsulated with liposomes and coated with ascorbic acid known for its antioxidant and immune-regulatory functions.The resulting nanoparticles,4TPE-C6T-TD@AA,effectively neutralize reactive oxygen species generated by lipopolysaccharides,facilitate the conversion of pro-inflammatory M1 macrophages to anti-inflammatory M2 macrophages,and eliminate>90%of Staphylococcus aureus and Escherichia coli by disrupting bacterial physiological functions upon exposure to 808 nm laser irradiation.In vivo experiments demonstrate that 4TPE-C6T-TD@AA rapidly eliminates bacteria from infected wounds in the maxi l lofacial region of rats,and significantly promotes healing in S.aureus-infected wounds by enhancing collagen formation and modulating the inflammatory microenvironment.In conclusion,this study presents a promising therapeutic strategy for effectively combating bacterial infections and excessive inflammation in treating maxi l lofacial injuries.

关 键 词：maxi l lofacial wound healing photothermal sterilization ANTI-INFLAMMATION 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]