刺激响应性药物载体及其材料的研究进展  

Research Progress of Stimuli-Responsive Carriers and Their Materials

作　　者：张雪妍 王珏[1] 王晓锋 贺刘莹 王会娟 杨锐[1] 赵霞[1] 孙会敏[1] ZHANG Xueyan;WANG Jue;WANG Xiaofeng;HE Liuying;WANG Huijuan;YANG Rui;ZHAO Xia;SUN Huimin(NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients,National Institutes for Food and Drug Control,Beijing 100050,China)

机构地区：[1]国家药品监督管理局药用辅料质量研究与评价重点实验室,中国食品药品检定研究院,北京100050

出　　处：《药学进展》2025年第2期111-125,共15页Progress in Pharmaceutical Sciences

摘　　要：刺激响应性药物载体因具有载药稳定性好、生物相容性好等特点而成为研究热点,通过各种内在或外在条件给予适当刺激,刺激响应性药物载体能达到药物靶点精准控制释放的目的。简介天然和人工合成的刺激响应性药物载体材料,内源性和外源性刺激响应性载体的作用机制及设计策略,刺激响应性药物载体及其材料的评价指标与技术,旨在为刺激响应性药物的研发、临床转化、评价监管提供参考。Stimuli-responsive drug carriers have become a research hotspot due to their good drug-loading stability and biocompatibility.By providing appropriate stimuli under various internal or external conditions,stimuli-responsive drug carriers can achieve precise controlled release of drugs at the target site.This paper briefly introduces the natural and artificially synthesized stimuli-responsive drug carrier materials,the mechanisms of action and design strategies of endogenous and exogenous stimuli-responsive carriers,evaluation indicators and techniques for stimuli-responsive drug carriers and their materials,aiming to provide some reference for the research and development,clinical translation,evaluation and supervision of stimuli-responsive drugs.

关 键 词：刺激响应性 药物载体 高分子材料 评价指标 

分 类 号：R944[医药卫生—药剂学]