基于“心与小肠相表里”理论探讨肠道菌群在脑-肠轴中与神经系统相关疾病的关联  

Relationship between Intestinal Flora and Nervous System Related Diseases in Brain-Gut Axis Based on Theory of“Heart and Small Intestine Being Exterior-Interiorly Related”

作　　者：刘慧慧[1] 单德红[1] 冷雪[1] LIU Huihui;SHAN Dehong;LENG Xue(College of Integrated Traditional Chinese and Western Medicine of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)

机构地区：[1]辽宁中医药大学中西医结合学院,辽宁沈阳110847

出　　处：《中华中医药学刊》2025年第3期133-135,I0031,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(82104552);辽宁省教育厅基本科研项目—面上项目(JYTMS20231822);辽宁省科技计划联合计划(自然科学基金-面上项目)(2024-MSLH-293);辽宁中医药大学中西医结合学院“岐济”人才支撑计划项目(2024QJ02003)。

摘　　要：神经系统相关疾病是目前影响威胁人类生命健康及生活质量最常见的疾病类型。“脑-肠轴”是脑和肠之间的双向交互通路,肠道菌群通过“脑-肠轴”的多途径影响神经系统相关疾病的发生发展,形成复杂的网络机制。通过探讨中医“心与小肠相表里”理论,探讨肠道菌群在“脑-肠轴”中的关键作用,以及与神经系统相关疾病发生发展的密切相关性,为“心与小肠相表里”中医理论与现代医学“脑-肠轴”理论的再认识和创新发展提供新的思路。Nervous system related diseases are the most common diseases that threaten human life,health and quality of life.“Brain-gut axis”is a two-way interactive pathway between brain and intestine.Intestinal flora affects the occurrence and de-velopment of nervous system related diseases through multiple pathways of brain-gut axis,forming a complex network mecha-nism.This paper discussed the theory of“heart and small intestine being exterior-interiorly related”in traditional Chinese med-icine,the key role of intestinal flora in the brain-gut axis and its close correlation with the occurrence and development of nerv-ous system related diseases,so as to provide new ideas for the re-understanding and innovative development of the theory of“heart and small intestine being exterior-interiorly related”in traditional Chinese medicine and the theory of“brain-gut axis”in modern medicine.

关 键 词：心与小肠相表里 肠道菌群 脑-肠轴 神经系统疾病 

分 类 号：R256.39[医药卫生—中医内科学]