妊娠期糖尿病患者血清T-AOC、IGF-1与胎儿生长受限的相关性  

Correlation Between Serum T-AOC,IGF-1,and Fetal Growth Restriction in Patients with Gestational Diabetes Mellitus

作　　者：吴允[1] 高颖[1] 王芳[1] 翟桂荣[1] 胡伟[1] WU Yun;GAO Ying;WANG Fang;ZHAI Guirong;HU Wei(Department of Obstetrics,Zhengzhou Maternal and Child Health Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]郑州市妇幼保健院产科,河南郑州450000

出　　处：《临床研究》2025年第3期54-57,共4页Clinical Research

摘　　要：目的探讨妊娠期糖尿病患者血清抗氧化能力(T-AOC)、胰岛素样生长因子-1(IGF-1)与胎儿生长受限的相关性。方法选取郑州市妇幼保健院2021年12月至2023年12月收治的60例妊娠期糖尿病患者,随防至分娩结束,根据是否发生胎儿生长受限分为发生组和未发生组。分析胎儿生长受限发生情况,比较发生组和未发生组基线资料及新生儿资料,分析血清T-AOC、IGF-1与新生儿体格发育指标的相关性,分析患者胎儿生长受限影响因素;分析血清T-AOC、IGF-1对胎儿生长受限的预测价值。结果60例患者中,发生胎儿生长受限17例,发生率为28.33%。发生组患者新生儿出生体重、头围小于未发生组,差异均有统计学意义(P<0.05),发生组血清T-AOC、IGF-1水平均低于未发生组,差异均有统计学意义(P<0.05)。患者血清T-AOC、IGF-1与新生儿出生体重、头围呈正相关,差异均有统计学意义(P<0.05)。血清T-AOC(OR=0.088,95%CI 0.021~0.375)、IGF-1(OR=0.820,95%CI 0.758~0.888)均是妊娠期糖尿病患者胎儿生长受限的影响因素,差异均有统计学意义(P<0.05)。血清T-AOC、IGF-1联合检测预测胎儿生长受限的曲线下面积(AUC)值高于单项检测,差异具有统计学意义(Z=2.342、0.207,P<0.05)。结论血清T-AOC、IGF-1水平与妊娠期糖尿病患者胎儿生长受限密切相关,临床可将其作为靶点治疗方案预防胎儿生长受限。Objective To explore the correlation between serum antioxidant capacity(T-AOC),insulin-like growth factor-1(IGF-1),and fetal growth restriction in patients with gestational diabetes mellitus.Methods A total of 60 patients with Gestational diabetes mellitus admitted to Zhengzhou Maternal and Child Health Hospital from December 2021 to December 2023 were selected and followed up until delivery.Patients were divided into a fetal growth restriction occurrence group and a nonoccurrence group based on whether fetal growth restriction occurred.The occurrence of fetal growth restriction was analyzed,and baseline and neonatal data were compared between the two groups.The correlations between serum T-AOC,IGF-1,and neonatal physical development indicators were analyzed to identify factors influencing fetal growth restriction in patients.Furthermore,the predictive value of serum T-AOC and IGF-1 for fetal growth restriction was assessed.Results Among the 60 patients,17 experienced fetal growth restriction,yielding an incidence rate of 28.33%.The birth weight and head circumference of neonates in the occurrence group were significantly lower than those in the non-occurrence group(P<0.05).The serum levels of T-AOC and IGF-1 in the occurrence group were also significantly lower than those in the non-occurrence group(P<0.05).Serum T-AOC and IGF-1 showed a positive correlation with neonatal birth weight and head circumference,with statistical significance(P<0.05).Serum T-AOC(OR=0.088,95%CI 0.021~0.375)and IGF-1(OR=0.820,95%CI 0.758~0.888)were identified as influencing factors of fetal growth restriction in patients with Gestational diabetes mellitus,with statistical significance(P<0.05).The combined detection of serum T-AOC and IGF-1 for predicting fetal growth restriction had a higher area under the curve(AUC)value compared to individual tests,showing statistical significance(Z=2.342,0.207,P<0.05).Conclusion Serum levels of T-AOC and IGF-1 are closely related to fetal growth restriction in patients with gestational diabetes melli

关 键 词：妊娠期糖尿病 胎儿生长受限 抗氧化能力 胰岛素样生长因子-1 预测价值 

分 类 号：R587.1[医药卫生—内分泌]