血栓弹力图与常规凝血功能检测在肺癌患者凝血功能评估中的临床应用价值分析  

Clinical Application Value Analysis of Thromboelastography and Routine Coagulation Function Tests in Coagulation Function Assessment of Lung Cancer Patients

作　　者：梅懿文 MEI Yiwen(Blood Transfusion Department,Nanyang Central Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市中心医院输血科,河南南阳473000

出　　处：《临床研究》2025年第3期147-150,共4页Clinical Research

摘　　要：目的探究血栓弹力图(TEG)在肺癌患者凝血功能评估中的应用价值。方法选取南阳市中心医院2023年1月至2024年2月收治的72例肺癌患者(研究组)与40例肺良性病变患者(对照组)作为研究对象,两组患者同时行常规凝血功能检测与TEG检查,比较两组检查结果。结果两组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)差异无统计学意义(P>0.05);研究组纤维蛋白原(FIB)、D-二聚体(D-D)、纤维蛋白降解产物(FDP)水平均高于对照组,差异均有统计学意义(P<0.05)。研究组凝血反应时间(R值)、血块生成时间(K值)低于对照组,血块生成率(α角)、血栓最大宽度值(MA值)、凝血综合指数(CI值)均高于对照组,差异均有统计学意义(P<0.05)。不同肿瘤分期患者PT、APTT、TT、FIB、FDP差异无统计学意义(P>0.05);Ⅲ~Ⅳ期患者D-D水平高于Ⅰ~Ⅱ期,差异具有统计学意义(P<0.05)。Ⅲ~Ⅳ期患者R值与K值低于Ⅰ~Ⅱ期,α角、MA值及CI值均高于Ⅰ~Ⅱ期,差异均有统计学意义(P<0.05)。结论与常规凝血功能检查相比,TEG检查能够更加全面、精准地评价不同分期肺癌患者的凝血功能,对疾病的诊疗与病情评估具有重要意义。Objective To explore the application value of thromboelastography(TEG)in assessing coagulation function in lung cancer patients.Methods A total of 72 lung cancer patients(study group)and 40 patients with benign lung lesions(control group)treated at Nanyang Central Hospital from January 2023 to February 2024 were selected as research subjects.Both groups underwent routine coagulation function tests and TEG examinations simultaneously,and the results were compared.Results There were no statistically significant differences in prothrombin time(PT),activated partial thromboplastin time(APTT),and thrombin time(TT)between the two groups(P>0.05).The levels of fibrinogen(FIB),D-dimer(D-D),and fibrin degradation products(FDP)in the study group were significantly higher than those in the control group(P<0.05).The coagulation reaction time(R value)and clot formation time(K value)in the study group were lower than those in the control group,while the clot formation rate(αangle),maximum amplitude(MA),and coagulation index(CI)were significantly higher than those in the control group(P<0.05).In patients with different tumor stages,there were no statistically significant differences in PT,APTT,TT,FIB,and FDP(P>0.05).Patients in stagesⅢtoⅣhad higher D-D levels compared to those in stagesⅠtoⅡ,which was statistically significant(P<0.05).The R value and K value in patients in stagesⅢtoⅣwere lower than those in stagesⅠtoⅡ,while theαangle,MA,and CI values were higher in stagesⅢtoⅣthan in stagesⅠtoⅡ,all showing statistically significant differences(P<0.05).Conclusion Compared to routine coagulation function tests,TEG provides a more comprehensive and accurate evaluation of coagulation function in lung cancer patients with different stages,which is significant for disease diagnosis,treatment,and assessment of the condition.

关 键 词：肺癌 凝血功能 血栓弹力图 纤维蛋白原 凝血反应时间 

分 类 号：R737.9[医药卫生—肿瘤]