加味四逆异功散治疗晚期大肠癌湿热瘀毒证疗效观察  

Efficacy observation of modified Sini Yigong powder on advanced colorectal cancer with syndrome of poisonous damp-heat and blood stasis

作　　者：梅灏 李思旋 MEI Hao;LI Si-xuan(Dianjiang Hospital of Traditional Chinese Medicine,Chongqing City,Dianjiang408300,China)

机构地区：[1]重庆市垫江县中医院,垫江408300

出　　处：《山西中医》2025年第3期29-31,共3页Shanxi Journal of Traditional Chinese Medicine

基　　金：重庆市垫江县社会民生科技创新项目(编号:djkjxm2022shmskjcxywzd016)。

摘　　要：目的:观察加味四逆异功散治疗晚期大肠癌湿热瘀毒证的临床疗效。方法:选取符合纳入标准的晚期大肠癌湿热瘀毒证患者80例,随机分为两组各40例。对照组予贝伐珠单抗+XELOX方案化疗,治疗组在对照组基础上予加味四逆异功散治疗。治疗12周后,比较两组实体瘤疗效、肿瘤标志物、中医证候疗效、生活质量以及不良反应。结果:治疗组临床缓解率45.00%,对照组临床缓解率22.50%,两组比较差异具有统计学意义(P﹤0.05);治疗组在中医证候积分、生活质量以及肿瘤标志物CEA、CA199的改善方面优于对照组,差异均有统计学意义(P﹤0.05);两组的不良反应发生率变化无明显差异(P﹥0.05)。结论:加味四逆异功散可控制晚期大肠癌湿热瘀毒证患者病情进展,提高其生活质量,临床疗效较好。Objective:To observe the clinical efficacy of modified Sini Yigong powder on advanced colorectal cancer with syndrome of poisonous damp-heat and blood stasis.Methods:80 cases of eligible patients with advanced colorectal cancer with syndrome of poisonous damp-heat and blood stasis were selected and randomly divided into two groups,40 cases in each group.The control group was treated with bevacizumab+XELOX regimen for chemotherapy,while the treatment group was treated plus with modified Sini Yigong powder on the basis of control group.Clinical efficacy of solid tumor,tumor markers,curative effect of TCM syndrome,quality of life and adverse reactions were compared between two groups after 12 weeks of treatment.Results:The clinical remission rate was 45.00%in the treatment group and 22.50%in the control group respectively,and the comparative difference between two groups was statistically significant(P﹤0.05).TCM syndrome score,quality of life and improvement of tumor markers such as CEA and CA199 of treatment group were better than those of control group,and the differences were statistically significant(P﹤0.05).There was no significant difference between two groups in incidence rate of adverse reactions(P﹥0.05).Conclusion:Modified Sini Yigong powder can control the disease progress of patients with advanced colorectal cancer with syndrome of poisonous damp-heat and blood stasis,and improve their quality of life.Its clinical efficacy is better.

关 键 词：大肠癌 加味四逆异功散 湿热瘀毒 中西医结合疗法 

分 类 号：R735.34[医药卫生—肿瘤]