上皮性卵巢癌组织UBR5、ITLN1表达及其对临床预后的影响  

The expression of UBR5 and ITLN1 in epithelial ovarian cancer tissues and their impact on clinical prognosis of EOC

作　　者：周司君 杨文静 杨慧君 云燕 萨日那 Zhou Sijun;Yang Wenjing;Yang Huijun;Yun Yan;Sa Rina(Department of Obstetrics and Gynecology,Inner Mongolia Autonomous Region People's Hospital,Inner Mongolia,Hohhot 737399,China)

机构地区：[1]内蒙古自治区人民医院妇产科,呼和浩特737399

出　　处：《疑难病杂志》2025年第3期285-289,302,共6页Chinese Journal of Difficult and Complicated Cases

基　　金：内蒙古自治区自然科学基金项目(2019MS0809)。

摘　　要：目的研究上皮性卵巢癌(EOC)中泛素蛋白连接酶E3组分N-识别蛋白5(UBR5)、内凝集蛋白1(ITLN1)的表达及其对预后的影响。方法回顾性选取2018年3月-2020年3月内蒙古自治区人民医院妇产科诊治EOC患者98例的临床资料,并以卵巢良性囊肿患者50例为对照组。采用免疫组化方法检测组织UBR5、ITLN1表达;Spearman秩相关分析UBR5与ITLN1的相关性。随访3年,绘制Kaplan-Meier曲线,比较UBR5、ITLN1表达与EOC患者预后的关系;Cox回归分析EOC患者预后影响因素。结果EOC组UBR5阳性率高于对照组,ITLN1阳性率低于对照组,差异均有统计学意义(χ^(2)/P=40.694/<0.001,40.597/<0.001);EOC中UBR5与ITLN1表达呈显著负相关(r s=-0.759,P<0.001);在FIGO分期Ⅲ期、有淋巴结转移患者中UBR5的阳性率高于FIGO分期Ⅰ~Ⅱ期、无淋巴结转移患者,ITLN1阳性率低于FIGO分期Ⅰ~Ⅱ期、无淋巴结转移患者(UBR5:χ^(2)/P=17.606/<0.001,20.103/<0.001;ITLN1:χ^(2)/P=10.303/0.006,13.131/<0.001);UBR5阳性亚组EOC患者3年累积生存率低于阴性亚组,ITLN1阴性亚组EOC患者3年累积生存率低于阳性亚组,差异均具有统计学意义(χ^(2)/P=6.803/0.009,11.090/0.001)。FIGO分期Ⅲ期、淋巴结转移、UBR5阳性是影响EOC预后的危险因素[HR(95%CI)=1.467(1.203~1.788),1.374(1.141~1.656),1.510(1.055~2.161)],ITLN1阳性是保护因素[HR(95%CI)=0.667(0.470~0.947)]。结论EOC中UBR5上调,ITLN1下调,与患者FIGO分期、淋巴结转移有关,均参与促进EOC肿瘤恶性进展,是新的预后评估的肿瘤标志物。Objective To investigate the expression of ubiquitin protein ligase E3 component N-recognition protein 5(UBR5)and internal agglutinin 1(ITLN1)in epithelial ovarian cancer(EOC)tissue,and to analyze the clinical prognostic value of their expression.Method A retrospective selection was conducted on 98 patients with EOC treated in the Obstetrics and Gynecology Department of Inner Mongolia Autonomous Region People's Hospital from March 2018 to March 2020,with 50 normal ovarian tissues as the control group.Immunohistochemistry was used to detect the expression of UBR5 and ITLN1 in tissues.Spearman rank correlation analysis was used to investigate the correlation between UBR5 and ITLN1.Follow up for 3 years,Kaplan-Meier curves were used to compare the prognostic differences between UBR5,ITLN1 positive and negative EOC patients.Cox regression analysis was used to analyze the prognostic factors in EOC patients.Results The positivity rate of UBR5 in EOC cancer tissue was higher than that in normal ovarian tissue,and the positivity rate of ITLN1 was lower than that in normal ovarian tissue,with statistical significance(χ^(2)/P=40.694/<0.001,40.597/<0.001).There was a significant negative correlation between UBR5 and ITLN1 expression in EOC(r s=-0.759,P<0.001).The positivity rate of UBR5 was higher in FIGO stageⅢ,with lymph node metastasis than in stageⅠ-Ⅱ,without lymph node metastasis;while the positivity rate of ITLN1 was lower in FIGO stageⅢ,with lymph node metastasis than in stageⅠ-Ⅱ,without lymph node metastasis(χ^(2)/P=17.606/<0.001,20.103/<0.001;10.303/0.006,13.131/<0.001);The 3-year cumulative survival rate of EOC patients in the UBR5 positive group was lower than that in the negative group,while the 3-year cumulative survival rate of EOC patients in the ITLN1 negative group was lower than that in the positive group,and the differences were statistically significant(χ^(2)/P=6.803/0.009,11.090/0.001).FIGO stageⅢ,lymph node metastasis,and UBR5 positivity were risk factors affecting the prognosis of EOC

关 键 词：上皮性卵巢癌 泛素蛋白连接酶E3组分N-识别蛋白5 内凝集蛋白1 预后 

分 类 号：R737.31[医药卫生—肿瘤]